Establishing and managing a periodontal biobank for research: the sharing of experience

Periodontal bio‐repositories, which allow banking of clinically validated human data and biological samples, provide an opportunity to derive biomarkers for periodontal diagnosis, prognosis and therapeutic activities which are expected to improve patient management. This article presents the establi...

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Bibliographic Details
Published in:Oral diseases 2015-01, Vol.21 (1), p.e62-e69
Main Authors: Vaithilingam, RD, Safii, SH, Baharuddin, NA, Karen-Ng, LP, Saub, R, Ariffin, F, Ramli, H, Sharifuddin, A, Hidayat, MFH, Raman, R, Chan, YK, Rani, NA, Rahim, RA, Shahruddin, N, Cheong, SC, Bartold, PM, Zain, RB
Format: Article
Language:English
Subjects:
biobanking
Biological Specimen Banks - ethics
Biological Specimen Banks - organization & administration
Biomarkers
Biomedical Research - ethics
Biomedical Research - methods
confidentiality
Cooperative Behavior
Dentistry
Gum disease
Humans
Informed consent
Medical research
Oral diseases
partnerships
Periodontal Diseases - pathology
periodontitis
Periodontium - anatomy & histology
specimen access
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Summary:Periodontal bio‐repositories, which allow banking of clinically validated human data and biological samples, provide an opportunity to derive biomarkers for periodontal diagnosis, prognosis and therapeutic activities which are expected to improve patient management. This article presents the establishing of the Malaysian Periodontal Database and Biobank System (MPDBS) which was initiated in 2011 with the aim to facilitate periodontal research. Partnerships were established with collaborating centres. Policies on specimen access, authorship and acknowledgement policies were agreed upon by all participating centres before the initiation of the periodontal biobank. Ethical approval for the collection of samples and data were obtained from institutional ethics review boards. A broad‐based approach for informed consent was used, which covered areas related to quality of life impacts, genetics and molecular aspects of periodontal disease. Sample collection and processing was performed using a standardized protocol. Biobanking resources such as equipment and freezers were shared with the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). In the development of the MPDBS, challenges that were previously faced by the MOCDTBS were considered. Future challenges in terms of ethical and legal issues will be faced when international collaborations necessitate the transportation of specimens across borders.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12267