Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2

Purpose Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding tr...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2014-05, Vol.70 (5), p.539-547
Main Authors: Ferrari, Marco, Guasti, Luigina, Maresca, Andrea, Mirabile, Mauro, Contini, Sara, Grandi, Anna Maria, Marino, Franca, Cosentino, Marco
Format: Article
Language:English
Subjects:
ATP Binding Cassette Transporter, Sub-Family B - genetics
ATP Binding Cassette Transporter, Sub-Family G, Member 2
ATP-Binding Cassette Transporters - genetics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Creatine Kinase - blood
Female
Genotype & phenotype
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Kinases
Male
Medical sciences
Middle Aged
Neoplasm Proteins - genetics
Organic Anion Transporters - genetics
Pharmacogenetics
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Polymorphism
Polymorphism, Single Nucleotide
Prospective Studies
Solute Carrier Organic Anion Transporter Family Member 1b1
Statins
Tissue Distribution - genetics
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Summary:Purpose Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding transporters involved in statin disposition. Methods Patients with and without statin-induced elevated serum CK levels were genotyped for polymorphisms in SLCO1B1 ( SLCO1B1 A388G and SLCO1B1 T521C), ABCB1 ( ABCB1 C1236T and ABCB1 C3435T) and ABCG2 ( ABCG2 C421A). Results Patients carrying SLCO1B1 T521C or ABCB1 C1236T single nucleotide polymorphisms (SNPs) had an odds ratio (OR) for statin-induced elevated serum CK levels of 8.86 ( p  
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-014-1661-6