Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population

Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genet...

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Bibliographic Details
Published in:Tumor biology 2014-05, Vol.35 (5), p.4937-4941
Main Authors: Dong, Yu-Shu, Hou, Wu-Gang, Li, Xiao-Lan, Jin, Tian-Bo, Li, Yue, Feng, Da-Yun, Liu, De-Bao, Gao, Guo-Dong, Yin, Zhong-Min, Qin, Huai-Zhou
Format: Article
Language:English
Subjects:
Asian Americans
Biomedical and Life Sciences
Biomedicine
Brain cancer
Brain Neoplasms - genetics
Cancer Research
Case-Control Studies
Checkpoint Kinase 2 - genetics
China - ethnology
DNA-Binding Proteins - genetics
Endonucleases - genetics
Female
Glioblastoma - genetics
Glutathione S-Transferase pi - genetics
Humans
Male
Polymorphism, Single Nucleotide
Population genetics
Reactive Oxygen Species - metabolism
Research Article
Tumors
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Summary:Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using χ 2 test and SNPStats, a website software. Using χ 2 test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 ( CHEK2 ), p  = 0.040; rs1695 in GSTP1 , p  = 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in GSTP1 decreased the risk of GBM in log-additive model (OR = 0.56, 95 % CI, 0.34–0.94, p  = 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 ( ERCC1 ) and gender under codominant and recessive models. The gene polymorphisms in CHEK2 , GSTP1 , and ERCC1 may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-1648-z