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Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population
Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genet...
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| Published in: | Tumor biology 2014-05, Vol.35 (5), p.4937-4941 |
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| container_end_page | 4941 |
| container_issue | 5 |
| container_start_page | 4937 |
| container_title | Tumor biology |
| container_volume | 35 |
| creator | Dong, Yu-Shu Hou, Wu-Gang Li, Xiao-Lan Jin, Tian-Bo Li, Yue Feng, Da-Yun Liu, De-Bao Gao, Guo-Dong Yin, Zhong-Min Qin, Huai-Zhou |
| description | Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using
χ
2
test and SNPStats, a website software. Using
χ
2
test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 (
CHEK2
),
p
= 0.040; rs1695 in
GSTP1
,
p
= 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in
GSTP1
decreased the risk of GBM in log-additive model (OR = 0.56, 95 % CI, 0.34–0.94,
p
= 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 (
ERCC1
) and gender under codominant and recessive models. The gene polymorphisms in
CHEK2
,
GSTP1
, and
ERCC1
may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed. |
| doi_str_mv | 10.1007/s13277-014-1648-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1639988864</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1521327542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-3d7dc082a4040d703225da6c8de068335e0044137cb3730d6b38606ecc2fb15c3</originalsourceid><addsrcrecordid>eNqFkc1qGzEURkVoyY_bB8gmCLrpItPeK2kkeRkG1w4NtLTutkKjkW2FseSMZijN02ccJ6UESlcS6NxP3O8Qco7wAQHUx4ycKVUAigKl0MX9ETlFwXgBXMOr8Q4IhWCan5CznG8BsJxO5TE5YaLkTDB1Sn7OffR9cNTmnFywfUiRphWtFrPP7JLOvy-_4iW1saGzb1WF9FfoN3TdhlS3Nvdpa2mItN94urCRVpsQffZ0l3ZD-xj1hrxe2Tb7t0_nhPz4NFtWi-Lmy_y6uropnFBlX_BGNQ40swIENAo4Y2VjpdONB6k5Lz2AEMiVq7ni0MiaawnSO8dWNZaOT8j7Q-6uS3eDz73Zhux829ro05ANSj6daq2l-D9asn2t5djjhLx7gd6moYvjInsKJEoci5wQPFCuSzl3fmV2Xdja7rdBMHtP5uDJjJ7M3pO5H2cunpKHeuubPxPPYkaAHYA8PsW17_76-p-pD5-CmdQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1520616145</pqid></control><display><type>article</type><title>Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population</title><source>Publicly Available Content Database</source><creator>Dong, Yu-Shu ; Hou, Wu-Gang ; Li, Xiao-Lan ; Jin, Tian-Bo ; Li, Yue ; Feng, Da-Yun ; Liu, De-Bao ; Gao, Guo-Dong ; Yin, Zhong-Min ; Qin, Huai-Zhou</creator><creatorcontrib>Dong, Yu-Shu ; Hou, Wu-Gang ; Li, Xiao-Lan ; Jin, Tian-Bo ; Li, Yue ; Feng, Da-Yun ; Liu, De-Bao ; Gao, Guo-Dong ; Yin, Zhong-Min ; Qin, Huai-Zhou</creatorcontrib><description>Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using
χ
2
test and SNPStats, a website software. Using
χ
2
test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 (
CHEK2
),
p
= 0.040; rs1695 in
GSTP1
,
p
= 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in
GSTP1
decreased the risk of GBM in log-additive model (OR = 0.56, 95 % CI, 0.34–0.94,
p
= 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 (
ERCC1
) and gender under codominant and recessive models. The gene polymorphisms in
CHEK2
,
GSTP1
, and
ERCC1
may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-014-1648-z</identifier><identifier>PMID: 24532427</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Asian Americans ; Biomedical and Life Sciences ; Biomedicine ; Brain cancer ; Brain Neoplasms - genetics ; Cancer Research ; Case-Control Studies ; Checkpoint Kinase 2 - genetics ; China - ethnology ; DNA-Binding Proteins - genetics ; Endonucleases - genetics ; Female ; Glioblastoma - genetics ; Glutathione S-Transferase pi - genetics ; Humans ; Male ; Polymorphism, Single Nucleotide ; Population genetics ; Reactive Oxygen Species - metabolism ; Research Article ; Tumors</subject><ispartof>Tumor biology, 2014-05, Vol.35 (5), p.4937-4941</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-3d7dc082a4040d703225da6c8de068335e0044137cb3730d6b38606ecc2fb15c3</citedby><cites>FETCH-LOGICAL-c475t-3d7dc082a4040d703225da6c8de068335e0044137cb3730d6b38606ecc2fb15c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1520616145?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25732,27903,27904,36991,36992,44569</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24532427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Yu-Shu</creatorcontrib><creatorcontrib>Hou, Wu-Gang</creatorcontrib><creatorcontrib>Li, Xiao-Lan</creatorcontrib><creatorcontrib>Jin, Tian-Bo</creatorcontrib><creatorcontrib>Li, Yue</creatorcontrib><creatorcontrib>Feng, Da-Yun</creatorcontrib><creatorcontrib>Liu, De-Bao</creatorcontrib><creatorcontrib>Gao, Guo-Dong</creatorcontrib><creatorcontrib>Yin, Zhong-Min</creatorcontrib><creatorcontrib>Qin, Huai-Zhou</creatorcontrib><title>Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using
χ
2
test and SNPStats, a website software. Using
χ
2
test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 (
CHEK2
),
p
= 0.040; rs1695 in
GSTP1
,
p
= 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in
GSTP1
decreased the risk of GBM in log-additive model (OR = 0.56, 95 % CI, 0.34–0.94,
p
= 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 (
ERCC1
) and gender under codominant and recessive models. The gene polymorphisms in
CHEK2
,
GSTP1
, and
ERCC1
may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed.</description><subject>Asian Americans</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Checkpoint Kinase 2 - genetics</subject><subject>China - ethnology</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Endonucleases - genetics</subject><subject>Female</subject><subject>Glioblastoma - genetics</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Research Article</subject><subject>Tumors</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFkc1qGzEURkVoyY_bB8gmCLrpItPeK2kkeRkG1w4NtLTutkKjkW2FseSMZijN02ccJ6UESlcS6NxP3O8Qco7wAQHUx4ycKVUAigKl0MX9ETlFwXgBXMOr8Q4IhWCan5CznG8BsJxO5TE5YaLkTDB1Sn7OffR9cNTmnFywfUiRphWtFrPP7JLOvy-_4iW1saGzb1WF9FfoN3TdhlS3Nvdpa2mItN94urCRVpsQffZ0l3ZD-xj1hrxe2Tb7t0_nhPz4NFtWi-Lmy_y6uropnFBlX_BGNQ40swIENAo4Y2VjpdONB6k5Lz2AEMiVq7ni0MiaawnSO8dWNZaOT8j7Q-6uS3eDz73Zhux829ro05ANSj6daq2l-D9asn2t5djjhLx7gd6moYvjInsKJEoci5wQPFCuSzl3fmV2Xdja7rdBMHtP5uDJjJ7M3pO5H2cunpKHeuubPxPPYkaAHYA8PsW17_76-p-pD5-CmdQ</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Dong, Yu-Shu</creator><creator>Hou, Wu-Gang</creator><creator>Li, Xiao-Lan</creator><creator>Jin, Tian-Bo</creator><creator>Li, Yue</creator><creator>Feng, Da-Yun</creator><creator>Liu, De-Bao</creator><creator>Gao, Guo-Dong</creator><creator>Yin, Zhong-Min</creator><creator>Qin, Huai-Zhou</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20140501</creationdate><title>Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population</title><author>Dong, Yu-Shu ; Hou, Wu-Gang ; Li, Xiao-Lan ; Jin, Tian-Bo ; Li, Yue ; Feng, Da-Yun ; Liu, De-Bao ; Gao, Guo-Dong ; Yin, Zhong-Min ; Qin, Huai-Zhou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-3d7dc082a4040d703225da6c8de068335e0044137cb3730d6b38606ecc2fb15c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Asian Americans</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - 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Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Yu-Shu</au><au>Hou, Wu-Gang</au><au>Li, Xiao-Lan</au><au>Jin, Tian-Bo</au><au>Li, Yue</au><au>Feng, Da-Yun</au><au>Liu, De-Bao</au><au>Gao, Guo-Dong</au><au>Yin, Zhong-Min</au><au>Qin, Huai-Zhou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>35</volume><issue>5</issue><spage>4937</spage><epage>4941</epage><pages>4937-4941</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using
χ
2
test and SNPStats, a website software. Using
χ
2
test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 (
CHEK2
),
p
= 0.040; rs1695 in
GSTP1
,
p
= 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in
GSTP1
decreased the risk of GBM in log-additive model (OR = 0.56, 95 % CI, 0.34–0.94,
p
= 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 (
ERCC1
) and gender under codominant and recessive models. The gene polymorphisms in
CHEK2
,
GSTP1
, and
ERCC1
may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24532427</pmid><doi>10.1007/s13277-014-1648-z</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-4283 |
| ispartof | Tumor biology, 2014-05, Vol.35 (5), p.4937-4941 |
| issn | 1010-4283 1423-0380 |
| language | eng |
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| source | Publicly Available Content Database |
| subjects | Asian Americans Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - genetics Cancer Research Case-Control Studies Checkpoint Kinase 2 - genetics China - ethnology DNA-Binding Proteins - genetics Endonucleases - genetics Female Glioblastoma - genetics Glutathione S-Transferase pi - genetics Humans Male Polymorphism, Single Nucleotide Population genetics Reactive Oxygen Species - metabolism Research Article Tumors |
| title | Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population |
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