Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

• Published in: Tumor biology 2014-05, Vol.35 (5), p.4983-4986
• Main Authors: de Araújo, Rubistenia Miranda Soares, de Melo, Cynthia Farias Vieira, Neto, Fidelis Manes, da Silva, Juarez Nóbrega, Soares, Leonardo Ferreira, de Arruda Cardoso Smith, Marilia, Sousa, Edilson Carvalho, Burbano, Rommel Mario Rodríguez, de Medeiros, Arnaldo Correia, Lima, Eleonidas Moura
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Brazil; Cancer; Cancer Research; Gastrointestinal diseases; Genes; Genetic Predisposition to Disease; Glutathione S-Transferase pi - genetics; Glutathione Transferase - genetics; Humans; Interferon gamma Receptor; Patients; Polymorphism; Polymorphism, Single Nucleotide; Receptors, Interferon - genetics; Research Article; Stomach Neoplasms - etiology; Stomach Neoplasms - genetics
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-014-1656-z

Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1 , GSTT1 , and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher’s exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed ( χ 2  = 8.73, P