Association of C722T polymorphism in XRCC3 gene with larynx cancer: a meta-analysis

Several case–control studies indicated that XRCC3 genetic polymorphism (C722T) was associated with larynx cancer. The present study aimed to further evaluate the relation between the XRCC3 gene C722T polymorphism and larynx cancer. We selected five case–control studies related to XRCC3 gene C722T po...

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Bibliographic Details
Published in:Tumor biology 2014-06, Vol.35 (6), p.5427-5430
Main Authors: Li, Dong, You, Hui-Hua, Jia, Yuan-Jing, Guo, Jian-Dong, Du, Huan-LE
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Case-Control Studies
DNA-Binding Proteins - genetics
Genes
Genetic Predisposition to Disease
Humans
Laryngeal cancer
Laryngeal Neoplasms - genetics
Meta-analysis
Polymorphism
Polymorphism, Genetic
Publication Bias
Research Article
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Summary:Several case–control studies indicated that XRCC3 genetic polymorphism (C722T) was associated with larynx cancer. The present study aimed to further evaluate the relation between the XRCC3 gene C722T polymorphism and larynx cancer. We selected five case–control studies related to XRCC3 gene C722T polymorphism and larynx cancer by searching PubMed, EMBase, Chinese CNKI, and Wanfang database. RevMan 5.0 software was used to perform the analysis. We directly utilized Q test and I 2 test to test the heterogeneity between each study. We utilized the fixed effects model to merge the odds ratio (OR) and 95 % confidence interval. There were 1,507 larynx cancer patients and 3,623 cancer-free control subjects included in the present study. By meta-analysis, we did not find any association of XRCC3 gene C722T polymorphism with larynx cancer [OR = 1.54, 95 % CI (0.77–3.08); P  = 0.22]. The present study indicated that XRCC3 gene C722T polymorphism was not associated with larynx cancer.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-1707-5