Comparison of matching by body volume or gestational age for calculation of observed to expected total lung volume in fetuses with isolated congenital diaphragmatic hernia

• Published in: Ultrasound in obstetrics & gynecology 2014-12, Vol.44 (6), p.655-660
• Main Authors: Nawapun, K., Sandaite, I., Dekoninck, P., Claus, F., Richter, J., De Catte, L., Deprest, J.
• Format: Article
• Language: English
• Subjects: Body Size; congenital diaphragmatic hernia; Cross-Sectional Studies; Female; fetal body volume; fetal lung volume; Fetuses; Gestational Age; Hernias; Hernias, Diaphragmatic, Congenital - diagnosis; Humans; Lung - abnormalities; Lung - embryology; Lung Volume Measurements; Magnetic Resonance Imaging; Observer Variation; Pregnancy; Prenatal Diagnosis - methods; Reproducibility of Results; Retrospective Studies
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.13356

ABSTRACT Objective To determine the bias induced by matching fetuses according to gestational age (GA) or fetal body volume (FBV) when calculating the observed to expected total fetal lung volume (o/e TFLV) in cases of isolated congenital diaphragmatic hernia (CDH). Methods This was a single‐center, retrospective study on archived magnetic resonance (MR) images of fetuses with isolated CDH over a 10‐year period. We retrieved the TFLV, GA and o/e TFLVGA, and delineated FBV to obtain TFLVFBV in each case. We evaluated the relationship between o/e TFLVFBV and o/e TFLVGA by Bland–Altman analysis. All outliers were manually identified, and their specific clinical features were retrieved. Results Records of a total of 377 MR examinations of 225 fetuses were identified and included in the analysis. The mean ( ± SD) time spent on FBV measurement was 16.12 ± 4.95 min. On reproducibility analysis of FBV measurement (n = 10), the intraobserver intraclass correlation coefficient (ICC) was 0.998 and the interobserver ICC was 0.999. FBV was highly correlated with GA (R2 = 0.899; P