Characterization of carvacrol beta-cyclodextrin inclusion complexes as delivery systems for antibacterial and antioxidant applications

Carvacrol is a good natural antimicrobial and antioxidant agent; however, its poor aqueous solubility and high volatility limit its application in food systems. Beta-cyclodextrin (ΒCD) is able to encapsulate hydrophobic molecules improving its aqueous solubility and reducing its volatility. ΒCD-carv...

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Bibliographic Details
Published in:Food science & technology 2015-01, Vol.60 (1), p.583-592
Main Authors: Santos, Emerson H., Kamimura, Juliane A., Hill, Laura E., Gomes, Carmen L.
Format: Article
Language:English
Subjects:
Antimicrobial activity
Beta-cyclodextrin inclusion complexes
Carvacrol
Escherichia coli
Natural antimicrobial
Salmonella enterica
Storage stability
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Summary:Carvacrol is a good natural antimicrobial and antioxidant agent; however, its poor aqueous solubility and high volatility limit its application in food systems. Beta-cyclodextrin (ΒCD) is able to encapsulate hydrophobic molecules improving its aqueous solubility and reducing its volatility. ΒCD-carvacrol inclusion complexes were prepared using kneading (KN) and freeze drying (FD) methods. Sizes of ΒCD-carvacrol complexes were 441 ± 12 nm and 899 ± 44 nm and entrapment efficiencies were 83.79 ± 2.89% and 91.31 ± 0.41% for KN and FD BCD-carvacrol complexes, respectively. Polydispersity index was higher (P 
ISSN:0023-6438
1096-1127
DOI:10.1016/j.lwt.2014.08.046