Sex differences in behavior and pro-inflammatory cytokine mRNA expression following stressor exposure and re-exposure

Highlights • Males and females demonstrate markedly different plus maze behaviors, even 6 weeks after stressors. • Stressors elicit sensitized expression of IL-1β in males but not females. • Baseline sex differences for cytokine expression are found in the hippocampus.

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Bibliographic Details
Published in:Neuroscience 2014-09, Vol.277, p.239-249
Main Authors: Hudson, S.P, Jacobson-Pick, S, Anisman, H
Format: Article
Language:English
Subjects:
Animals
anxiety
cytokine
Exploratory Behavior - physiology
Hippocampus - physiopathology
Interleukin-1beta - metabolism
Interleukin-6 - metabolism
Maze Learning
Mice
Neurology
Neuropsychological Tests
Prefrontal Cortex - physiopathology
Random Allocation
Receptors, Interleukin-1 - metabolism
Receptors, Interleukin-6 - metabolism
Receptors, Tumor Necrosis Factor - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Sex Characteristics
sex differences
stress
Stress, Psychological - physiopathology
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:Highlights • Males and females demonstrate markedly different plus maze behaviors, even 6 weeks after stressors. • Stressors elicit sensitized expression of IL-1β in males but not females. • Baseline sex differences for cytokine expression are found in the hippocampus.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.07.007