Disruption of redox homeostasis and histopathological alterations caused by in vivo intrastriatal administration of D-2-hydroxyglutaric acid to young rats

Highlights • D-2-HG induces lipid and protein oxidative damage in the rat striatum in vivo. • D-2-HG compromises antioxidant defenses in the rat striatum in vivo. • MK-801, L-NAME and creatine prevent D-2-HG-induced oxidative stress in the rat striatum. • Oxidative stress may be involved in the neur...

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Bibliographic Details
Published in:Neuroscience 2014-09, Vol.277, p.281-293
Main Authors: da Rosa, M.S, Seminotti, B, Amaral, A.U, Parmeggiani, B, de Oliveira, F.H, Leipnitz, G, Wajner, M
Format: Article
Language:English
Subjects:
Animals
brain damage
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Corpus Striatum - pathology
Creatine - pharmacology
D-2-hydroxyglutaric acid
D-2-hydroxyglutaric aciduria
Dizocilpine Maleate - pharmacology
Glutarates - metabolism
Glutarates - pharmacology
Glutarates - toxicity
Glutathione - metabolism
Lipid Peroxidation - drug effects
Lipid Peroxidation - physiology
Malondialdehyde - metabolism
N-Methylaspartate - metabolism
Neurology
Neuroprotective Agents - pharmacology
NG-Nitroarginine Methyl Ester - pharmacology
Oxidative Stress - drug effects
Oxidative Stress - physiology
Rats
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - metabolism
redox homeostasis
striatum
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Summary:Highlights • D-2-HG induces lipid and protein oxidative damage in the rat striatum in vivo. • D-2-HG compromises antioxidant defenses in the rat striatum in vivo. • MK-801, L-NAME and creatine prevent D-2-HG-induced oxidative stress in the rat striatum. • Oxidative stress may be involved in the neuropathology of D-2-HGA.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.07.011