Contribution of Ih to the relative facilitation of synaptic responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the parasubiculum

• Published in: Neuroscience 2014-10, Vol.278, p.81-92
• Main Authors: Sparks, D.W, Chapman, C.A
• Format: Article
• Language: English
• Subjects: acetylcholine; Acetylcholine - pharmacology; Action Potentials - drug effects; Animals; Carbachol - pharmacology; Cholinergic Agonists - pharmacology; Electric Stimulation; entorhinal cortex; Entorhinal Cortex - drug effects; Entorhinal Cortex - physiology; Excitatory Postsynaptic Potentials - drug effects; Hippocampus - drug effects; Hippocampus - physiology; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology; IKir; Male; Neural Pathways - drug effects; Neural Pathways - physiology; Neurology; NMDA; parasubiculum; Potassium Channels - physiology; Pyrimidines - pharmacology; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - physiology; Valine - analogs & derivatives; Valine - pharmacology
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.08.005

Highlights • The parasubiculum projects to layer II of the entorhinal cortex. • The cholinergic agonist carbachol reduces Ih and facilitates synaptic responses during θ- and γ-frequency trains. • Blocking Ih with ZD7288 mimics the facilitation induced by carbachol and increases input resistance. • ZD7288 also results in similar facilitation effects during blockade of Kir channels with Ba2+. • Cholinergic suppression of Ih may promote neuronal communication during θ and γ EEG activities.