Prediction of skin permeation by chemical compounds using the artificial membrane, Strat-M

The usefulness of the synthetic membrane, Strat-M™ as an alternative to human and animal skins was evaluated by estimating the skin permeabilities of chemical compounds. Thirteen chemical compounds with molecular weights (M.W.) of 152–289 and lipophilicities (log Ko/w) of −0.9 to 3.5 were selected....

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2015-01, Vol.67, p.113-118
Main Authors: Uchida, Takashi, Kadhum, Wesam R., Kanai, Sayumi, Todo, Hiroaki, Oshizaka, Takeshi, Sugibayashi, Kenji
Format: Article
Language:English
Subjects:
1-Octanol - chemistry
Alternative membrane
Animals
Female
Humans
In Vitro Techniques
Male
Membrane permeation
Membranes, Artificial
Middle Aged
Pharmaceutical Preparations - metabolism
Rats, Hairless
Skin
Skin - metabolism
Skin Absorption
Strat-M
Synthetic membrane
Water - chemistry
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Summary:The usefulness of the synthetic membrane, Strat-M™ as an alternative to human and animal skins was evaluated by estimating the skin permeabilities of chemical compounds. Thirteen chemical compounds with molecular weights (M.W.) of 152–289 and lipophilicities (log Ko/w) of −0.9 to 3.5 were selected. Strat-M™, excised human skin, or hairless rat skin was set in a Franz-type diffusion cell and a saturated solution of each chemical compound was applied to determine membrane permeation profiles. The obtained permeability coefficients (log P) were compared among these membranes. Elevations were observed in log P for Strat-M™ with an increase in the log Ko/w of the applied compounds, and similar results were observed with the human and hairless rat skins. A correlation was obtained in log P values between Strat-M™ and human or hairless rat skin. Furthermore, the diffusion and partition parameters of chemicals in Strat-M™ were similar to those in the excised human and rat skins. These results suggest that Strat-M™ could be used as an alternative to animal or human skin in permeation studies.
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2014.11.002