Chinese medicine herbal treatment based on syndrome differentiation improves the overall survival of patients with unresectable hepatocellular carcinoma

Objective To investigate the effects of Chinese medicine (CM) herbal treatment based on syndrome differentiation on patients with unresectable hepatocellular carcinoma (HCC). Methods A total of 94 patients with unresectable HCC were reviewed between June 2008 and June 2011. Survival analysis was per...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2015, Vol.21 (1), p.49-57
Main Authors: Man, Ya-nan, Liu, Xiao-hui, Wu, Xiong-zhi
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Clinical Experience
Combined Modality Therapy
Drugs, Chinese Herbal - therapeutic use
Female
Humans
Kaplan-Meier Estimate
Liver Neoplasms - drug therapy
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Prognosis
Survival Analysis
Syndrome
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Summary:Objective To investigate the effects of Chinese medicine (CM) herbal treatment based on syndrome differentiation on patients with unresectable hepatocellular carcinoma (HCC). Methods A total of 94 patients with unresectable HCC were reviewed between June 2008 and June 2011. Survival analysis was performed between patients who received CM with/without non-curative antitumor treatments of Western medicine (WM) (CM group, 30 cases) and patients who were not treated with CM but with non-curative antitumor treatments of WM or supportive treatment alone (non-CM group, 64 cases). Then, survival analysis was performed between patients treated with CM combined with non-curative antitumor treatments of WM (combination therapy group, 25 cases) and patients with non-curative antitumor treatments of WM alone (non-curative antitumor treatments group of WM, 52 cases). The survival analysis was performed by Kaplan-Meier method and prognostic factors for overall survival (OS) were assessed by the Cox proportional hazards regression model. Results The median survival time (MST), 1- and 2-year survival rates of the CM group and the non-CM group were 36 months, 76.7%, 56.1% and 12 months, 48.4%, 26.6%, respectively. The Log-rank test revealed significant difference between the two groups in OS ( P
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-014-1767-9