Langmuir Monolayers and Thin Films of Amphifilic Thiacalix[4]arenes. Properties and Matrix for the Immobilization of Cytochrome c

Formation and properties of Langmuir films of thiacalix[4]­arene (TCA) derivatives containing N-donor groups on the lower rim (YO­(CH2)3CN; OCH2CN; NH2; OCH2ArCN-p) in 1,3-alternate conformation on aqueous subphase and solid substrates have been studied. Only tetra-cyanopropoxy-p-tert-butylthiacali...

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Bibliographic Details
Published in:Langmuir 2014-12, Vol.30 (50), p.15153-15161
Main Authors: Solovieva, Svetlana E, Safiullin, Roman A, Kochetkov, Evgeni N, Melnikova, Nina B, Kadirov, Marsil K, Popova, Elena V, Antipin, Igor S, Konovalov, Alexander I
Format: Article
Language:English
Subjects:
Animals
Cattle
Cytochromes c - chemistry
Enzymes, Immobilized - chemistry
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Molecular Conformation
Phenols - chemistry
Sulfides - chemistry
Surface Properties
Water - chemistry
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Summary:Formation and properties of Langmuir films of thiacalix[4]­arene (TCA) derivatives containing N-donor groups on the lower rim (YO­(CH2)3CN; OCH2CN; NH2; OCH2ArCN-p) in 1,3-alternate conformation on aqueous subphase and solid substrates have been studied. Only tetra-cyanopropoxy-p-tert-butylthiacalix­[4]­arene 1 forms a typical monomolecular layer with perpendicular orientation of the macrocycle relative to the water–air interface that is able to immobilize cytochrome c in the entire range of the surface pressure. Obtained monolayers were transferred by Langmuir–Schaefer technique onto quartz, indium–tin oxide (ITO), and silicon. It was demonstrated that protein activity is retained after immobilization on the substrate.
ISSN:0743-7463
1520-5827
DOI:10.1021/la504379v