Very Low-Carbohydrate Ketogenic Diet Before Bariatric Surgery: Prospective Evaluation of a Sequential Diet

Background We evaluated the effectiveness of a sequential diet regimen termed the obese preoperative diet (OPOD) in morbidly obese patients with and without type 2 diabetes mellitus (T2DM) scheduled for laparoscopic bariatric surgery. Methods Fifty patients (body mass index 53.5 ± 8.4 kg/m 2 ) sched...

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Bibliographic Details
Published in:Obesity surgery 2015, Vol.25 (1), p.64-71
Main Authors: Leonetti, Frida, Campanile, Fabio Cesare, Coccia, Federica, Capoccia, Danila, Alessandroni, Laura, Puzziello, Alessandro, Coluzzi, Ilenia, Silecchia, Gianfranco
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Bariatric Surgery - methods
Blood Glucose - metabolism
Body Mass Index
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diet therapy
Diabetes Mellitus, Type 2 - surgery
Diet
Diet, Carbohydrate-Restricted
Diet, Ketogenic
Female
Gastrointestinal surgery
Humans
Laparoscopy - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity
Obesity, Morbid - complications
Obesity, Morbid - diet therapy
Obesity, Morbid - surgery
Original Contributions
Preoperative Period
Prospective Studies
Surgery
Weight control
Weight Loss - physiology
Young Adult
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Summary:Background We evaluated the effectiveness of a sequential diet regimen termed the obese preoperative diet (OPOD) in morbidly obese patients with and without type 2 diabetes mellitus (T2DM) scheduled for laparoscopic bariatric surgery. Methods Fifty patients (body mass index 53.5 ± 8.4 kg/m 2 ) scheduled for bariatric surgery, including 14 with T2DM, were prospectively enrolled and followed the OPOD regimen: a very low-calorie ketogenic diet for 10 days, followed by a very low-calorie diet for 10 days, and then a low-calorie diet for 10 days. Patients were evaluated at baseline ( T 0) and after 10 days ( T 1), 20 days ( T 2), and 30 days ( T 3). Results Body weight, body mass index, waist circumference, and neck circumference were significantly lower at T 1, T 2, and T 3 than at T 0 in the 48 patients who completed the OPOD. Two patients discontinued the OPOD after 4–7 days. In patients with T2DM, fasting plasma glucose levels decreased significantly, enabling reduction of diabetic medications. Plasma and urine ketone levels increased at T 1 but were all
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-014-1348-1