Diagnostic significance of diffusion-weighted MRI in patients with cervical cancer: a meta-analysis

The aim of this meta-analysis is to demonstrate whether diffusion-weighted magnetic resonance imaging (DWI) could assist in the precise diagnosis of cervical cancer or not. Both English and Chinese electronic databases were searched for potential relevant studies followed by a comprehensive literatu...

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Bibliographic Details
Published in:Tumor biology 2014-12, Vol.35 (12), p.11761-11769
Main Authors: Hou, Bo, Xiang, Shi-Feng, Yao, Gen-Dong, Yang, Su-Jun, Wang, Yu-Fang, Zhang, Yi-Xin, Wang, Jun-Wei
Format: Article
Language:English
Subjects:
Biomedicine
Cancer Research
Case-Control Studies
Cervical cancer
Diffusion Magnetic Resonance Imaging
Female
Humans
Medical diagnosis
Meta-analysis
NMR
Nuclear magnetic resonance
Odds Ratio
Research Article
Sensitivity and Specificity
Uterine Cervical Neoplasms - diagnosis
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Summary:The aim of this meta-analysis is to demonstrate whether diffusion-weighted magnetic resonance imaging (DWI) could assist in the precise diagnosis of cervical cancer or not. Both English and Chinese electronic databases were searched for potential relevant studies followed by a comprehensive literature search without any language restriction. Two reviewers independently assessed the methodological quality of the included trials. Standardized mean difference (SMD) and its corresponding 95 % confidence interval (95 % CI) were calculated in this meta-analysis. We chose Version 12.0 STATA statistical software to analyze our statistical data. Thirteen eligible cohort studies were selected for statistical analysis, including 645 tumor tissues and 504 normal tissues. Combined SMD of apparent diffusion coefficient (ADC) suggested that the ADC value in cervical cancer tissues was significantly lower than that of normal tissue (SMD = 2.80, 95 % CI = 2.64 ~ 2.96, P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-2290-5