Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma

Increasing evidence demonstrated that Chitinase 3-like 1 (hereafter termed CHI3L1 or YKL-40) was highly expressed and tightly associated with human tumor development and progression. However, its precise role in clear cell renal cell carcinoma (hereafter termed RCC) remains to be delineated. In the...

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Bibliographic Details
Published in:Tumor biology 2014-12, Vol.35 (12), p.12131-12137
Main Authors: Zhang, Jian-Ping, Yuan, Hai-Xia, Kong, Wen-Tao, Liu, Yujun, Lin, Zong-Ming, Wangs, Wen-Ping, Guo, Jian-Ming
Format: Article
Language:English
Subjects:
Adipokines - genetics
Adipokines - metabolism
Adult
Aged
Aged, 80 and over
Biomedicine
Blood vessels
Cancer Research
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Chitinase-3-Like Protein 1
Density
Female
Gene Expression
Glycoproteins
Humans
Immunohistochemistry
Kidney cancer
Kidney Neoplasms - metabolism
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Lectins - genetics
Lectins - metabolism
Male
Medical prognosis
Metastasis
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Neovascularization, Pathologic
Prognosis
Research Article
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Summary:Increasing evidence demonstrated that Chitinase 3-like 1 (hereafter termed CHI3L1 or YKL-40) was highly expressed and tightly associated with human tumor development and progression. However, its precise role in clear cell renal cell carcinoma (hereafter termed RCC) remains to be delineated. In the present study, we investigated the relationship between CHI3L1 expression and microvessel density (MVD), a reflection of angiogenesis, with metastasis and prognosis in patients with clear cell renal cell carcinoma (RCC). Formalin-fixed, paraffin-embedded tissue sections of clear cell RCC from 73 patients who had undergone radical nephrectomy were stained immunohistochemically with specific antibodies against CHI3L1 and CD34. CHI3L1 immunostaining was semi-quantitatively estimated based on the proportion (percentage of positive cells) and intensity. MVD was determined with CD34-stained slides. The expression pattern of CHI3L1 and MVD was compared with the clinicopathological variables. Twenty patients had either synchronous or metachronous metastases and 12 died during the follow-up. CHI3L1 intensity was significantly correlated with tumor size ( P  = 0.005), TNM stage ( P  = 0.027), M stage ( P  = 0.011), grade ( P  = 0.014), and metastasis (synchronous or metachronous; P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-2518-4