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The antinociceptive effects of branched-chain amino acids: Evidence for their ability to potentiate morphine analgesia
The effect of branched-chain amino acids (BCAA) on pain threshold was studied in rats. Nociception was induced by the hot-plate analgesia meter, a method measuring supraspinally organized pain responses. After a single intravenous injection of BCAA (320 mg/kg), the percent change in latency time to...
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Published in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-02, Vol.53 (2), p.449-454 |
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creator | Manner, T. Katz, D.P. Askanazi, J. |
description | The effect of branched-chain amino acids (BCAA) on pain threshold was studied in rats. Nociception was induced by the hot-plate analgesia meter, a method measuring supraspinally organized pain responses. After a single intravenous injection of BCAA (320 mg/kg), the percent change in latency time to the pain response significantly increased by 19% in 60 min, and by 22% in 75 min (
p < 0.005), as compared to an injection of an equal volume of a standard concentration of an amino acid solution or physiological saline. Subsequently, we studied the interaction of BCAA with opioid-type analgesia. In combination with intravenously injected morphine (3 mg/kg), BCAA significantly potentiated and prolonged the action of morphine using the hot-plate test. From 5 min after morphine injection, the latencies to a pain response were markedly higher with the combination of BCAA and morphine (+ 80% and + 89% at 5 min after morphine injection, if BCAA was administered 45 or 60 min prior to morphine injection, respectively) when compared with the effect of morphine alone (+ 13% at 5 min;
p < 0.005). BCAA demonstrated analgesic effects, which, in combination with morphine, potentiated and prolonged the antinociceptive action of morphine. BCAA may represent a new adjunct treatment modality for acute and chronic pain, and give us further insight into the mechanisms of pain control. |
doi_str_mv | 10.1016/0091-3057(95)02016-0 |
format | article |
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p < 0.005), as compared to an injection of an equal volume of a standard concentration of an amino acid solution or physiological saline. Subsequently, we studied the interaction of BCAA with opioid-type analgesia. In combination with intravenously injected morphine (3 mg/kg), BCAA significantly potentiated and prolonged the action of morphine using the hot-plate test. From 5 min after morphine injection, the latencies to a pain response were markedly higher with the combination of BCAA and morphine (+ 80% and + 89% at 5 min after morphine injection, if BCAA was administered 45 or 60 min prior to morphine injection, respectively) when compared with the effect of morphine alone (+ 13% at 5 min;
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p < 0.005), as compared to an injection of an equal volume of a standard concentration of an amino acid solution or physiological saline. Subsequently, we studied the interaction of BCAA with opioid-type analgesia. In combination with intravenously injected morphine (3 mg/kg), BCAA significantly potentiated and prolonged the action of morphine using the hot-plate test. From 5 min after morphine injection, the latencies to a pain response were markedly higher with the combination of BCAA and morphine (+ 80% and + 89% at 5 min after morphine injection, if BCAA was administered 45 or 60 min prior to morphine injection, respectively) when compared with the effect of morphine alone (+ 13% at 5 min;
p < 0.005). BCAA demonstrated analgesic effects, which, in combination with morphine, potentiated and prolonged the antinociceptive action of morphine. BCAA may represent a new adjunct treatment modality for acute and chronic pain, and give us further insight into the mechanisms of pain control.</description><subject>Amino Acids, Branched-Chain - pharmacology</subject><subject>Analgesics</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Antinociception</subject><subject>Biological and medical sciences</subject><subject>Branched-chain amino acids</subject><subject>Drug Synergism</subject><subject>Hot Temperature</subject><subject>Hot-plate analgesia test</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pain</subject><subject>Pain Threshold - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi1EVZbCPwDJB1TBIWA78Uc4IFVVoUiVuJSz5dhjYpTEwfau1H-Pw672yMkazzOvrWcQekPJR0qo-ERIT5uWcPm-5x8Iq1cNeYZ2VMm24VTK52h3Rl6glzn_JoR0TMhLdKkUUZTLHTo8joDNUsISbbCwlnAADN6DLRlHj4dkFjuCa-xowoLNXEFsbHD5M747BAeLBexjwmWEkLAZwhTKEy4Rr7FAzTUF8BzTOoZle8hMvyAH8wpdeDNleH06r9DPr3ePt_fNw49v329vHhrbUVkaypRzSg3APB1AUGoYCCaUF0qCk6bnW-kkN5ZQ5kG1wDs5GEZaQaUX7RW6PuauKf7ZQy56DtnCNJkF4j5rKjrCGW8r2B1Bm2LOCbxeU5hNetKU6E233lzqzaXuuf6nW5M69vaUvx9mcOehk9_af3fqm2zN5DebIZ8x1qtWdF3FvhwxqC4OAZLONmxqXUh1E9rF8P9__AVNLJyj</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Manner, T.</creator><creator>Katz, D.P.</creator><creator>Askanazi, J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope></search><sort><creationdate>19960201</creationdate><title>The antinociceptive effects of branched-chain amino acids: Evidence for their ability to potentiate morphine analgesia</title><author>Manner, T. ; Katz, D.P. ; Askanazi, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-128dd88be2f1be611a2e6268f687ed7a95e626d75ac012fe83e547ba203617f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acids, Branched-Chain - pharmacology</topic><topic>Analgesics</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Antinociception</topic><topic>Biological and medical sciences</topic><topic>Branched-chain amino acids</topic><topic>Drug Synergism</topic><topic>Hot Temperature</topic><topic>Hot-plate analgesia test</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pain</topic><topic>Pain Threshold - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manner, T.</creatorcontrib><creatorcontrib>Katz, D.P.</creatorcontrib><creatorcontrib>Askanazi, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manner, T.</au><au>Katz, D.P.</au><au>Askanazi, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antinociceptive effects of branched-chain amino acids: Evidence for their ability to potentiate morphine analgesia</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>53</volume><issue>2</issue><spage>449</spage><epage>454</epage><pages>449-454</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The effect of branched-chain amino acids (BCAA) on pain threshold was studied in rats. Nociception was induced by the hot-plate analgesia meter, a method measuring supraspinally organized pain responses. After a single intravenous injection of BCAA (320 mg/kg), the percent change in latency time to the pain response significantly increased by 19% in 60 min, and by 22% in 75 min (
p < 0.005), as compared to an injection of an equal volume of a standard concentration of an amino acid solution or physiological saline. Subsequently, we studied the interaction of BCAA with opioid-type analgesia. In combination with intravenously injected morphine (3 mg/kg), BCAA significantly potentiated and prolonged the action of morphine using the hot-plate test. From 5 min after morphine injection, the latencies to a pain response were markedly higher with the combination of BCAA and morphine (+ 80% and + 89% at 5 min after morphine injection, if BCAA was administered 45 or 60 min prior to morphine injection, respectively) when compared with the effect of morphine alone (+ 13% at 5 min;
p < 0.005). BCAA demonstrated analgesic effects, which, in combination with morphine, potentiated and prolonged the antinociceptive action of morphine. BCAA may represent a new adjunct treatment modality for acute and chronic pain, and give us further insight into the mechanisms of pain control.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8808157</pmid><doi>10.1016/0091-3057(95)02016-0</doi><tpages>6</tpages></addata></record> |
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subjects | Amino Acids, Branched-Chain - pharmacology Analgesics Analgesics - pharmacology Analgesics, Opioid - pharmacology Animals Antinociception Biological and medical sciences Branched-chain amino acids Drug Synergism Hot Temperature Hot-plate analgesia test Male Medical sciences Morphine - pharmacology Neuropharmacology Pain Pain Threshold - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley |
title | The antinociceptive effects of branched-chain amino acids: Evidence for their ability to potentiate morphine analgesia |
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