Immunologic function in horses after non-specific immunostimulant administration

Inactivated Propionibacterium acnes is a biologic response modifier for treatment of non-specific respiratory disease in horses. The objectives of this investigation were to determine alterations in phagocytic activity, phenotypic expression of lymphocyte subpopulations and lymphokine-activated kill...

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Published in:Veterinary immunology and immunopathology 1998-06, Vol.63 (4), p.299-311
Main Authors: Julia B.F. Flaminio, M, Rush, B R, Shuman, W
Format: Article
Language:English
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Summary:Inactivated Propionibacterium acnes is a biologic response modifier for treatment of non-specific respiratory disease in horses. The objectives of this investigation were to determine alterations in phagocytic activity, phenotypic expression of lymphocyte subpopulations and lymphokine-activated killing cell response in healthy young horses. Samples were collected on day 0, 7 and 14 of the investigation. Blood samples were obtained via jugular venipuncture and pulmonary leukocytes were recovered via bronchoalveolar lavage (BAL). Commercially available P. acnes (Eqstim registered ) was administered intravenously on days 7, 9 and 11 of the investigation. Fever was observed on days 8 and 10, indicating manifestation of immune reaction. Total peripheral blood white cell count was increased ( P
ISSN:0165-2427