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Dendritic alterations in cortical pyramidal cells in the sparse fur mouse
Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur ( spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both...
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Published in: | Brain research 1998-06, Vol.797 (1), p.167-172 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in
sparse fur (
spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in
spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in
spf/Y mice. |
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ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/S0006-8993(98)00392-8 |