Loading…

Dendritic alterations in cortical pyramidal cells in the sparse fur mouse

Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur ( spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1998-06, Vol.797 (1), p.167-172
Main Authors: Hopkins, Keri J, McKean, J, Mervis, Ronald F, Oster-Granite, Mary Lou
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur ( spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in spf/Y mice.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00392-8