Iron metabolism after application of modified magnetite nanoparticles in rats

The influence of modified nanosized magnetite (NSM) particles (magnetic microspheres coated with chitosan and magnetoliposomes) after a single intravenous infusion of their suspensions on iron metabolism in rats has been studied. Modern physical and chemical methods (X-ray fluorescence, dynamic ligh...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2014-11, Vol.79 (11), p.1245-1254
Main Authors: Milto, I. V., Grishanova, A. Yu, Klimenteva, T. K., Suhodolo, I. V., Vasukov, G. Yu, Ivanova, V. V.
Format: Article
Language:English
Subjects:
Analysis
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Chemical properties
Chitin
Coatings
Emission spectroscopy
Ferritin
Health aspects
Iron
Iron - blood
Iron - metabolism
Iron in the body
Kidney - metabolism
Life Sciences
Light scattering
Liposomes
Liver - metabolism
Lung - metabolism
Magnetic properties
Magnetite
Magnetite Nanoparticles - administration & dosage
Magnetite Nanoparticles - ultrastructure
Male
Metabolism
Metalloenzymes
Microbiology
Microscopy, Electron, Transmission
Mineral metabolism
Minerals
Nanoparticles
Physiological aspects
Properties
Rats
Rats as laboratory animals
Rodents
Spectrometry, X-Ray Emission
Spectrophotometry, Atomic
Spleen - metabolism
Tissue Distribution
Transferrin
X-ray fluorescence
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Description
Summary:The influence of modified nanosized magnetite (NSM) particles (magnetic microspheres coated with chitosan and magnetoliposomes) after a single intravenous infusion of their suspensions on iron metabolism in rats has been studied. Modern physical and chemical methods (X-ray fluorescence, dynamic light scattering, transmission electron microscopy) were used for standardization of the modified NSM particles (their size, structure, ζ-potential, and concentration were determined). Atomic emission spectroscopy was used to reveal the dynamics of iron content in rat liver, spleen, lungs, and kidneys during 120 days. Colorimetric and immunoturbidimetric methods were used to determine the concentrations of plasma iron and the proteins involved in its metabolism — ceruloplasmin, transferrin, and ferritin. Their dynamics through- out the experiments were studied.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297914110121