Comparison of Therapeutic Effects of Magnesium Sulfate vs. Dexamethasone/Metoclopramide on Alleviating Acute Migraine Headache

Abstract Background There is controversy about the efficacy of currently used treatment modalities to alleviate migraine headaches. Objective We aimed to evaluate and compare the effects of magnesium sulfate and combined use of dexamethasone/metoclopramide on relieving acute migraine headache. Metho...

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Bibliographic Details
Published in:The Journal of emergency medicine 2015-01, Vol.48 (1), p.69-76
Main Authors: Shahrami, Ali, MD, Assarzadegan, Farhad, MD, Hatamabadi, Hamid Reza, MD, Asgarzadeh, Morteza, MPH, PhD, Sarehbandi, Baharak, MD, Asgarzadeh, Setareh, MD
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Analgesics - therapeutic use
Anti-Inflammatory Agents - therapeutic use
dexamethasone
Dexamethasone - therapeutic use
Dopamine D2 Receptor Antagonists - therapeutic use
Double-Blind Method
Drug Combinations
Emergency
Female
Humans
Infusions, Intravenous
magnesium sulfate
Magnesium Sulfate - therapeutic use
Male
metoclopramide
Metoclopramide - therapeutic use
Middle Aged
migraine
Migraine Disorders - drug therapy
Time Factors
treatment
Young Adult
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Summary:Abstract Background There is controversy about the efficacy of currently used treatment modalities to alleviate migraine headaches. Objective We aimed to evaluate and compare the effects of magnesium sulfate and combined use of dexamethasone/metoclopramide on relieving acute migraine headache. Methods We randomly divided 70 patients who had been referred to an emergency department, into two equal treatment groups with the two treatment plans, and analyzed pain severity at baseline using a numeric rating scale (NRS). We gave dexamethasone/metoclopramide to one group and magnesium sulfate to the other group, and evaluated pain severity at 20 min and at 1- and 2-h intervals after infusion. Finally, we used repeated-measure and two-way analysis of variance for intra- and inter-group evaluations of pain severity and complications, respectively. Results We found no significant differences in demographic data and pain severity at baseline (8.2 vs. 8.0) between the two groups ( p  
ISSN:0736-4679
2352-5029
DOI:10.1016/j.jemermed.2014.06.055