Determination of the molecular dynamics of alamethicin using super(13)C NMR: Implications for the mechanism of gating of a voltage-dependent channel

Alamethicin is a channel-forming peptide antibiotic that produces a highly voltage-dependent conductance in planar bilayers. To provide insight into the mechanisms for its voltage dependence, the dynamics of the peptide were examined in solution using nuclear magnetic resonance.

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Bibliographic Details
Published in:Biochemistry (Easton) 1992-01, Vol.31 (22), p.5136-5144
Main Authors: Kelsh, L P, Ellena, J F, Cafiso, D S
Format: Article
Language:English
Subjects:
alamethicin
antibiotics
channels
formation
N.M.R
structure
Online Access:Get full text
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Description
Summary:Alamethicin is a channel-forming peptide antibiotic that produces a highly voltage-dependent conductance in planar bilayers. To provide insight into the mechanisms for its voltage dependence, the dynamics of the peptide were examined in solution using nuclear magnetic resonance.
ISSN:0006-2960