Fasting serum dipeptidyl peptidase-4 activity is independently associated with alanine aminotransferase in type 1 diabetic patients

Dipeptidyl peptidase-4 (DPP4) was recently proposed as a novel adipokine linked to insulin resistance (IR). As IR represents a cluster of disorders in hepatic and muscle cell insulin signalisation, we aimed to assess the possible correlation between fasting serum DPP4 activity, IR and liver enzymes...

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Bibliographic Details
Published in:Clinical biochemistry 2015-01, Vol.48 (1-2), p.39-43
Main Authors: Blaslov, Kristina, Bulum, Tomislav, Knežević-Ćuća, Jadranka, Duvnjak, Lea
Format: Article
Language:English
Subjects:
Adult
Alanine aminotranfrerase
Alanine Transaminase - blood
Biomarkers - blood
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - enzymology
Dipeptidyl Peptidase 4 - blood
Dipeptidyl peptidase-4
Fasting - blood
Female
Humans
Linear Models
Liver - metabolism
Male
Middle Aged
Type 1 diabetes
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Summary:Dipeptidyl peptidase-4 (DPP4) was recently proposed as a novel adipokine linked to insulin resistance (IR). As IR represents a cluster of disorders in hepatic and muscle cell insulin signalisation, we aimed to assess the possible correlation between fasting serum DPP4 activity, IR and liver enzymes in order to elucidate the question of hepatic contribution to serum DPP4 activity. This cross-sectional study comprised 44 T1DM patients aged 18 to 65years. IR was estimated using the equation derived from euglycemic–hyperinsulinemic clamp studies-estimated glucose disposal rate (eGDR). DPP4 serum activity was determined spectrophotometrically as a rate of cleavage of 7-amino-4-methyl coumarin (AMC) from H-Gly-Pro-AMC. The patients were divided into two groups according to the mean value of fasting serum DPP4 activity (31.42U/L). The group with lower fasting serum DPP4 activity had lower mean rate of liver biomarkers alanine aminotransferase (ALT) (p=0.001) and aspartate aminotransferase (AST) (p=0.002) while higher eGDR (p=0.003) compared to group with higher DPP4 activity. DPP4 activity showed positive correlation with AST (r=0.358, p=0.017) and ALT (r=0.364, p=0.015) while negative correlation with eGDR (r=−0.612, p
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2014.10.006