Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

KEY CLINICAL MESSAGEGene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematol...

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Bibliographic Details
Published in:Clinical case reports 2014, Vol.2 (6), p.265-270
Main Authors: Xiang, Zhifu, Kaur, Varinder, Aburiziq, Ibrahim K, Mehta, Paulette, Emanuel, Peter, Schichman, Steven A
Format: Report
Language:English
Online Access:Get full text
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Summary:KEY CLINICAL MESSAGEGene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.110