Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma

Objectives/Hypothesis To determine the prognostic value of hypoxia‐associated markers carbonic anhydrase‐9 (CA‐9) and hypoxia‐inducible factor‐1α (HIF‐1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. Study Design Retrospective cohort stu...

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Bibliographic Details
Published in:The Laryngoscope 2015-01, Vol.125 (1), p.E8-E15
Main Authors: Bernstein, Jonathan M., Andrews, Timothy D., Slevin, Nick J., West, Catharine M. L., Homer, Jarrod J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - blood
biomarker
Biomarkers, Tumor - blood
CA-9
Carbonic Anhydrase IX
Carbonic Anhydrases - blood
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Cervical cancer
Classification
Clinical outcomes
Disease Progression
Disease-Free Survival
Female
Head and neck squamous cell carcinoma
HIF-1α
Humans
Hypopharyngeal Neoplasms - mortality
Hypopharyngeal Neoplasms - pathology
hypopharynx
Hypopharynx - pathology
Hypoxia
Hypoxia - pathology
Hypoxia-Inducible Factor 1, alpha Subunit - blood
Immunoenzyme Techniques
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - pathology
Larynx
Larynx - pathology
Male
Medical prognosis
Middle Aged
Mortality
Multivariate analysis
Neoplasm Staging
Prognosis
Tumor Burden - physiology
tumor hypoxia
tumor volume
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Summary:Objectives/Hypothesis To determine the prognostic value of hypoxia‐associated markers carbonic anhydrase‐9 (CA‐9) and hypoxia‐inducible factor‐1α (HIF‐1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. Study Design Retrospective cohort study. Methods Pretreatment CA‐9 and HIF‐1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3–4 SCCa larynx or hypopharynx treated by (chemo)radiation. Results Adverse prognostic factors for locoregional control were T4 classification (P = 0.008), and for disease‐specific survival were CA‐9 positivity (P = 0.039), T4 classification (P = 0.001), larger tumor volume (P = 0.004), N1–3 classification (P = 0.002), and pretreatment hemoglobin 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.24933