Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice

The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1998-03, Vol.19 (3), p.529-531
Main Authors: PAZOS, P, LANARI, C, ELIZALDE, P, MONTECCHIA, F, CHARREAU, E. H, MOLINOLO, A. A
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemically induced
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - toxicity
Chemical agents
Cocarcinogenesis
Female
Mammary Neoplasms, Experimental - chemically induced
Medical sciences
Medroxyprogesterone Acetate - toxicity
Methylnitrosourea - toxicity
Mice
Mice, Inbred BALB C
Tumors
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Summary:The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions.
ISSN:0143-3334
1460-2180
1460-2180
DOI:10.1093/carcin/19.3.529