Molecular and genetic damage in humans from environmental pollution in Poland

We used a battery of biological markers to measure molecular and genetic damage in peripheral blood samples from residents of Silesia and from persons living in a rural, less polluted area of Poland. The results show that their exposure to environmental pollution is associated with significant incre...

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Bibliographic Details
Published in:Nature (London) 1992-01, Vol.369 (6401), p.256-258
Main Authors: Perera, F P, Hemminki, K, Gryzobowska, E, Motykiewicz, G, Michalska, J, Santella, R M, Young, Tie-Lan, Dickey, C, Chorazy, M
Format: Article
Language:English
Subjects:
adducts
air sampling
damage
DNA
expression
formation
man
oncogenes
pollution
pollution effects
public health
ras
ras gene
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Summary:We used a battery of biological markers to measure molecular and genetic damage in peripheral blood samples from residents of Silesia and from persons living in a rural, less polluted area of Poland. The results show that their exposure to environmental pollution is associated with significant increases in carcinogen-DNA adducts (PAH-DNA and aromatic adducts), in sister chromatid exchange including high-frequency cells, and in chromosomal aberrations as well as a doubling in the frequency of ras oncogene overexpression. We found that aromatic adducts on DNA were significantly correlated with chromosomal mutation, providing us with a molecular link between environmental exposure and a genetic alteration relevant to cancer and reproductive risk.
ISSN:0028-0836