Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats

Laminar profiles of rises in [K +] o and slow field potentials induced by alvear stimulation were recorded in area CA1 of hippocampal slices from control and pilocarpine-treated rats in absence and presence of Ba 2+. In control animals, Ba 2+ augmented rises in [K +] o in stratum pyramidale (SP) as...

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Bibliographic Details
Published in:Neuroscience letters 1998-02, Vol.242 (1), p.9-12
Main Authors: Gabriel, S, Eilers, A, Kivi, A, Kovacs, R, Schulze, K, Lehmann, T.-N, Heinemann, U
Format: Article
Language:English
Subjects:
Animals
Area CA1
Barium - pharmacology
Biological and medical sciences
Epilepsy, Temporal Lobe - chemically induced
Epilepsy, Temporal Lobe - metabolism
Extracellular Space - metabolism
Glia
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampal sclerosis
Hippocampus - drug effects
Hippocampus - metabolism
In Vitro Techniques
K + Regulation
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Perfusion
Pilocarpine
Pilocarpine - pharmacology
Potassium - metabolism
Rats
Rats, Wistar
Scopolamine - pharmacology
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Summary:Laminar profiles of rises in [K +] o and slow field potentials induced by alvear stimulation were recorded in area CA1 of hippocampal slices from control and pilocarpine-treated rats in absence and presence of Ba 2+. In control animals, Ba 2+ augmented rises in [K +] o in stratum pyramidale (SP) as well as in stratum radiatum (SR). In pilocarpine-treated animals an augmentation of rises in [K +] o was restricted to SP and its immediate vicinity. Moreover, the effect of Ba 2+ in SP was small or missing in eight out of 15 slices of pilocarpine-treated animals. In these slices laminar profiles of rises in [K +] o were not affected by Ba 2+. It is suggested that spatial K +-buffering is reduced in area CA1 of epileptic animals.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(98)00012-3