Vaginal preparation with povidone iodine disinfection and saline douching as a safe and effective method in prevention of oocyte pickup-associated pelvic inflammation without spoiling the reproductive outcome: evidence from a large cohort study

• Published in: Clinical and experimental obstetrics & gynecology 2014-01, Vol.41 (6), p.689-690
• Main Authors: Funabiki, M, Taguchi, S, Hayashi, T, Tada, Y, Kitaya, K, Iwaki, Y, Karita, M, Nakamura, Y
• Format: Article
• Language: English
• Subjects: Adult; Cohort Studies; Disinfection; Female; Fertilization in Vitro - methods; Humans; Oocyte Retrieval - adverse effects; Pelvic Inflammatory Disease - prevention & control; Povidone-Iodine - pharmacology; Pregnancy; Sodium Chloride; Therapeutic Irrigation; Vagina
• ISSN: 0390-6663
• DOI: 10.12891/ceog18772014

The aim of this study was to investigate if vaginal preparation procedure affects the occurrence of oocyte pickup-associated pelvic inflammation (OPU-PI) and the reproductive outcome in an in vitro fertilization (IVF) program. The occurrence of OPU-PI and the reproductive outcome were compared between 956 infertile patients undergoing vaginal preparation with saline douching alone versus 1,216 infertile patients undergoing a combination ofpovidone iodine disinfection and subsequent saline douching in an IVF program. OPU-PI occurred in four patients (0.042%) in the saline douching alone group, whereas there were no cases in the combination group (p = 0.016). There were no significant differences in the rate of fertilization, morphologically good embryo acquisition, clinical and ongoing pregnancy between the two groups (p > 0.23). This large cohort study demonstrated that a combination of vaginal povidone iodine disinfection and subsequent saline douching is more effective procedure than saline douching alone to prevent OPU-PI, without spoiling the oocyte quality.