Pediatric germ cell tumors from 1987 to 2011: incidence rates, time trends, and survival

Malignant germ cell tumors (GCTs) are a rare and a heterogeneous group of pediatric cancers. The incidence rate has increased in some populations or subgroups. However, only a few recent publications on epidemiologic data showing the trends in incidence of pediatric GCTs are available. We analyzed t...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2015-01, Vol.135 (1), p.e136-e143
Main Authors: Kaatsch, Peter, Häfner, Carla, Calaminus, Gabriele, Blettner, Maria, Tulla, Mira
Format: Article
Language:English
Subjects:
Adolescent
Analysis
Cancer
Cancer survivors
Cells
Child
Child, Preschool
Children
Children & youth
Epidemiology
Female
Germ cell tumors
Germinoma
Health aspects
Humans
Infant
Male
Neoplasms, Germ Cell and Embryonal - epidemiology
Pediatrics
Risk factors
Survival Rate
Time Factors
Tumors
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Summary:Malignant germ cell tumors (GCTs) are a rare and a heterogeneous group of pediatric cancers. The incidence rate has increased in some populations or subgroups. However, only a few recent publications on epidemiologic data showing the trends in incidence of pediatric GCTs are available. We analyzed the incidence rates, time trends, and survival for 1366 GCTs in children 0 to 14 years old registered in the nationwide, population-based German Childhood Cancer Registry in 1987-2011. The incidence rate of GCTs was slightly higher in girls (age-standardized rate: girls, 5.3; boys, 4.4 per million). A bimodal age distribution was seen. In children aged
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2014-1989