Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new me...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-07, Vol.50 (54), p.7139-7142
Main Authors: Marculescu, Cristina, Kossen, Hanno, Morgan, Rachel E, Mayer, Patrick, Fletcher, Sally A, Tolner, Berend, Chester, Kerry A, Jones, Lyn H, Baker, James R
Format: Article
Language:English
Subjects:
Attenuation
Bridging
Chemical bonds
Cysteine
Cysteine - chemistry
Disulfides
Disulfides - chemistry
GRB2 Adaptor Protein - chemistry
Maleimides - chemical synthesis
Maleimides - chemistry
Proteins
Somatostatin - chemistry
Tuning
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Summary:Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc02107j