Plant-derived epigenetic modulators for cancer treatment and prevention

Carcinogenesis is a complex and multistep process that involves the accumulation of successive transformational events driven by genetic mutations and epigenetic alterations that affect major cellular processes and pathways such as proliferation, differentiation, invasion and survival. Massive dereg...

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Bibliographic Details
Published in:Biotechnology advances 2014-11, Vol.32 (6), p.1123-1132
Main Authors: Schnekenburger, Michael, Dicato, Mario, Diederich, Marc
Format: Article
Language:English
Subjects:
Alterations
Animals
Antineoplastic Agents
Apoptosis
Biological and medical sciences
Biotechnology
Cancer
Cancer prevention
Cancer therapy
Carcinogens
Cell death
Cell Line, Tumor
Cellular
Clinical trials
Differentiation
Epigenesis, Genetic - drug effects
Epigenetics
Fundamental and applied biological sciences. Psychology
Gene expression
Humans
Machinery
Mice
Natural compounds
Neoplasms - drug therapy
Neoplasms - prevention & control
Plant Extracts
Proliferation
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Summary:Carcinogenesis is a complex and multistep process that involves the accumulation of successive transformational events driven by genetic mutations and epigenetic alterations that affect major cellular processes and pathways such as proliferation, differentiation, invasion and survival. Massive deregulation of all components of the epigenetic machinery is a hallmark of cancer. These alterations affect normal gene regulation and impede normal cellular processes including cell cycle, DNA repair, cell growth, differentiation and apoptosis. Since epigenetic alterations appear early in cancer development and represent potentially initiating events during carcinogenesis, they are considered as promising targets for anti-cancer interventions by chemopreventive and chemotherapeutic strategies using epigenetically active agents. In this field, plant-derived compounds have shown promise. Here, we will give an overview of plant-derived compounds displaying anticancer properties that interfere with the epigenetic machinery. •Epigenetic alterations are a cancer hallmark•Epimutations are promising targets for anti-cancer interventions•Many phytochemicals are active against epigenetic modifiers•Early epigenetic alterations represent targets for chemoprevention•The chemopreventive properties of phytochemicals rely on their epigenetic activity
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2014.03.009