Activation of the ubiquitin–proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis

Highlights • Parkin is an E3 ubiquitin ligase involved in mitochondrial homeostasis. • Arsenic trioxide activates Parkin as well as the proteasome in HL-1 cells. • In contrast, little activation of autophagy was observed. • Parkin appears to be involved in the maintenance of HL-1 cell homeostasis....

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2014-08, Vol.322, p.43-50
Main Authors: Watanabe, Mayumi, Funakoshi, Takeshi, Unuma, Kana, Aki, Toshihiko, Uemura, Koichi
Format: Article
Language:English
Subjects:
Activation
Animals
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Arsenic trioxide
Arsenicals
Autophagy - drug effects
Blotting, Western
Boronic Acids - pharmacology
Bortezomib
Cardiomyocyte
Cellular
Emergency
Exposure
Heart Diseases - chemically induced
Heart Diseases - prevention & control
HL-1
Homeostasis
Homeostasis - drug effects
Immunoprecipitation
Inhibitors
Lysosomes - drug effects
Membrane Potential, Mitochondrial - drug effects
Mice
Microscopy, Fluorescence
Mitochondria
Mitochondria, Heart - drug effects
Mitophagy
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Oxides - toxicity
Parkin
Proteasome Endopeptidase Complex - drug effects
Pyrazines - pharmacology
Toxicity
Ubiquitin - drug effects
Ubiquitin-Protein Ligases - physiology
Ubiquitin–proteasome system
UPS
Voltage-Dependent Anion Channel 1 - biosynthesis
Voltage-Dependent Anion Channel 1 - genetics
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Summary:Highlights • Parkin is an E3 ubiquitin ligase involved in mitochondrial homeostasis. • Arsenic trioxide activates Parkin as well as the proteasome in HL-1 cells. • In contrast, little activation of autophagy was observed. • Parkin appears to be involved in the maintenance of HL-1 cell homeostasis.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2014.04.008