Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management

Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular ge...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2014-09, Vol.1323 (1), p.22-42
Main Authors: Temkin, Elizabeth, Adler, Amos, Lerner, Anat, Carmeli, Yehuda
Format: Article
Language:English
Subjects:
Alleles
Antibiotics
antimicrobial resistance
Biology
carbapenem-resistant Enterobacteriaceae
carbapenemases
Carbapenems - pharmacology
CRE bacteria
Drug Resistance, Microbial - genetics
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - diagnosis
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Epidemiology
Genetics
Health risks
infection control
Management
molecular genetics
Organisms
Promoter Regions, Genetic
Public health
treatment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.12537