Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management

Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular ge...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2014-09, Vol.1323 (1), p.22-42
Main Authors: Temkin, Elizabeth, Adler, Amos, Lerner, Anat, Carmeli, Yehuda
Format: Article
Language:English
Subjects:
Alleles
Antibiotics
antimicrobial resistance
Biology
carbapenem-resistant Enterobacteriaceae
carbapenemases
Carbapenems - pharmacology
CRE bacteria
Drug Resistance, Microbial - genetics
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - diagnosis
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Epidemiology
Genetics
Health risks
infection control
Management
molecular genetics
Organisms
Promoter Regions, Genetic
Public health
treatment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813
cites cdi_FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813
container_end_page 42
container_issue 1
container_start_page 22
container_title Annals of the New York Academy of Sciences
container_volume 1323
creator Temkin, Elizabeth
Adler, Amos
Lerner, Anat
Carmeli, Yehuda
description Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.
doi_str_mv 10.1111/nyas.12537
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1642267963</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3422640171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813</originalsourceid><addsrcrecordid>eNqN0U1LHDEYB_AgFd1aL_0AZaEXKR2bl8lbb7L4BrIWqoin8GTmGRk7k9kms9j99s12XQ891ObyEPjlT5I_Ie8ZPWZ5fQkrSMeMS6F3yITp0hZKCf6GTCjVujCWi33yNqVHShk3pd4j-1wyK62wEzKfQfSwwIB9ETG1aYQwTk_DiHHwUOXRQoWAX6e-HbrhYfV5iou2xn67g1BPewjwgD2G8R3ZbaBLePg8D8jt2enN7KK4uj6_nJ1cFZVUQhdalyi9bzynFhkV0kjgVoFi3pTAKYjGl541jaopgKkVCM2UUqy23ijDxAE52uQu4vBziWl0fZsq7DoIOCyTY6rkXGmrxOtUKpV_RWvzPzRflnNDM_34F30cljHkN2clrdWWlWv1aaOqOKQUsXGL2PYQV45Rt-7Orbtzf7rL-MNz5NL3WL_QbVkZsA14ajtc_SPKze9Pvm9Di82Z3Cz-ejkD8YdTWmjp7ubnjt3xb_zsQjgqfgM097FR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1559979140</pqid></control><display><type>article</type><title>Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Temkin, Elizabeth ; Adler, Amos ; Lerner, Anat ; Carmeli, Yehuda</creator><creatorcontrib>Temkin, Elizabeth ; Adler, Amos ; Lerner, Anat ; Carmeli, Yehuda</creatorcontrib><description>Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/nyas.12537</identifier><identifier>PMID: 25195939</identifier><identifier>CODEN: ANYAA9</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alleles ; Antibiotics ; antimicrobial resistance ; Biology ; carbapenem-resistant Enterobacteriaceae ; carbapenemases ; Carbapenems - pharmacology ; CRE bacteria ; Drug Resistance, Microbial - genetics ; Enterobacteriaceae ; Enterobacteriaceae - drug effects ; Enterobacteriaceae Infections - diagnosis ; Enterobacteriaceae Infections - drug therapy ; Enterobacteriaceae Infections - epidemiology ; Enterobacteriaceae Infections - microbiology ; Epidemiology ; Genetics ; Health risks ; infection control ; Management ; molecular genetics ; Organisms ; Promoter Regions, Genetic ; Public health ; treatment</subject><ispartof>Annals of the New York Academy of Sciences, 2014-09, Vol.1323 (1), p.22-42</ispartof><rights>2014 New York Academy of Sciences.</rights><rights>2014 The New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813</citedby><cites>FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25195939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Temkin, Elizabeth</creatorcontrib><creatorcontrib>Adler, Amos</creatorcontrib><creatorcontrib>Lerner, Anat</creatorcontrib><creatorcontrib>Carmeli, Yehuda</creatorcontrib><title>Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann. N.Y. Acad. Sci</addtitle><description>Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.</description><subject>Alleles</subject><subject>Antibiotics</subject><subject>antimicrobial resistance</subject><subject>Biology</subject><subject>carbapenem-resistant Enterobacteriaceae</subject><subject>carbapenemases</subject><subject>Carbapenems - pharmacology</subject><subject>CRE bacteria</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Enterobacteriaceae</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae Infections - diagnosis</subject><subject>Enterobacteriaceae Infections - drug therapy</subject><subject>Enterobacteriaceae Infections - epidemiology</subject><subject>Enterobacteriaceae Infections - microbiology</subject><subject>Epidemiology</subject><subject>Genetics</subject><subject>Health risks</subject><subject>infection control</subject><subject>Management</subject><subject>molecular genetics</subject><subject>Organisms</subject><subject>Promoter Regions, Genetic</subject><subject>Public health</subject><subject>treatment</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqN0U1LHDEYB_AgFd1aL_0AZaEXKR2bl8lbb7L4BrIWqoin8GTmGRk7k9kms9j99s12XQ891ObyEPjlT5I_Ie8ZPWZ5fQkrSMeMS6F3yITp0hZKCf6GTCjVujCWi33yNqVHShk3pd4j-1wyK62wEzKfQfSwwIB9ETG1aYQwTk_DiHHwUOXRQoWAX6e-HbrhYfV5iou2xn67g1BPewjwgD2G8R3ZbaBLePg8D8jt2enN7KK4uj6_nJ1cFZVUQhdalyi9bzynFhkV0kjgVoFi3pTAKYjGl541jaopgKkVCM2UUqy23ijDxAE52uQu4vBziWl0fZsq7DoIOCyTY6rkXGmrxOtUKpV_RWvzPzRflnNDM_34F30cljHkN2clrdWWlWv1aaOqOKQUsXGL2PYQV45Rt-7Orbtzf7rL-MNz5NL3WL_QbVkZsA14ajtc_SPKze9Pvm9Di82Z3Cz-ejkD8YdTWmjp7ubnjt3xb_zsQjgqfgM097FR</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Temkin, Elizabeth</creator><creator>Adler, Amos</creator><creator>Lerner, Anat</creator><creator>Carmeli, Yehuda</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7SP</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>201409</creationdate><title>Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management</title><author>Temkin, Elizabeth ; Adler, Amos ; Lerner, Anat ; Carmeli, Yehuda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alleles</topic><topic>Antibiotics</topic><topic>antimicrobial resistance</topic><topic>Biology</topic><topic>carbapenem-resistant Enterobacteriaceae</topic><topic>carbapenemases</topic><topic>Carbapenems - pharmacology</topic><topic>CRE bacteria</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Enterobacteriaceae</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Enterobacteriaceae Infections - diagnosis</topic><topic>Enterobacteriaceae Infections - drug therapy</topic><topic>Enterobacteriaceae Infections - epidemiology</topic><topic>Enterobacteriaceae Infections - microbiology</topic><topic>Epidemiology</topic><topic>Genetics</topic><topic>Health risks</topic><topic>infection control</topic><topic>Management</topic><topic>molecular genetics</topic><topic>Organisms</topic><topic>Promoter Regions, Genetic</topic><topic>Public health</topic><topic>treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Temkin, Elizabeth</creatorcontrib><creatorcontrib>Adler, Amos</creatorcontrib><creatorcontrib>Lerner, Anat</creatorcontrib><creatorcontrib>Carmeli, Yehuda</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Temkin, Elizabeth</au><au>Adler, Amos</au><au>Lerner, Anat</au><au>Carmeli, Yehuda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann. N.Y. Acad. Sci</addtitle><date>2014-09</date><risdate>2014</risdate><volume>1323</volume><issue>1</issue><spage>22</spage><epage>42</epage><pages>22-42</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><coden>ANYAA9</coden><abstract>Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem‐resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25195939</pmid><doi>10.1111/nyas.12537</doi><tpages>21</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0077-8923
ispartof Annals of the New York Academy of Sciences, 2014-09, Vol.1323 (1), p.22-42
issn 0077-8923
1749-6632
language eng
recordid cdi_proquest_miscellaneous_1642267963
source Wiley-Blackwell Read & Publish Collection
subjects Alleles
Antibiotics
antimicrobial resistance
Biology
carbapenem-resistant Enterobacteriaceae
carbapenemases
Carbapenems - pharmacology
CRE bacteria
Drug Resistance, Microbial - genetics
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - diagnosis
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Epidemiology
Genetics
Health risks
infection control
Management
molecular genetics
Organisms
Promoter Regions, Genetic
Public health
treatment
title Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T05%3A03%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carbapenem-resistant%20Enterobacteriaceae:%20biology,%20epidemiology,%20and%20management&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=Temkin,%20Elizabeth&rft.date=2014-09&rft.volume=1323&rft.issue=1&rft.spage=22&rft.epage=42&rft.pages=22-42&rft.issn=0077-8923&rft.eissn=1749-6632&rft.coden=ANYAA9&rft_id=info:doi/10.1111/nyas.12537&rft_dat=%3Cproquest_cross%3E3422640171%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5637-774e5bbfb209e103585a296a61b84a20a3fb4b1ff6d0aa8d6a3716661d9b86813%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1559979140&rft_id=info:pmid/25195939&rfr_iscdi=true