Occurrences of major polybrominated diphenyl ethers (PBDEs) in maternal and fetal cord blood sera in Korea

• Published in: The Science of the total environment 2014-09, Vol.491-492, p.219-226
• Main Authors: Choi, Gyuyeon, Kim, Sungjoo, Kim, Sunmi, Kim, Sungkyoon, Choi, Youngeun, Kim, Hai-Joong, Lee, Jeong Jae, Kim, Su Young, Lee, Sunggyu, Moon, Hyo-Bang, Choi, Sooran, Choi, Kyungho, Park, Jeongim
• Format: Article
• Language: English
• Subjects: Adult; BDE-153; BDE-47; BDE-99; Environmental Pollutants - blood; Female; Fetal Blood - metabolism; Halogenated Diphenyl Ethers - blood; Humans; Infant; Infant, Newborn; Maternal Exposure - statistics & numerical data; Pregnancy; Pregnant women; Republic of Korea; Transplacental
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2014.02.071

Polybrominated diphenyl ethers (PBDEs) are of growing public health concern because of their potential toxicities which range from endocrine disruption to neurodevelopment. However, information on their exposure among sensitive human populations is limited. The objectives of this study were to determine the levels of major PBDEs in blood sera of pregnant women and their matching newborn infants. For this purpose, a total of 198 maternal blood samples and 118 matching umbilical cord blood samples were collected from four regions of South Korea in 2011, and were determined for 19 PBDE congeners. Various demographic, dietary, and behavioral characteristics were asked in a questionnaire survey. Average concentration of total PBDEs in maternal blood serum was 3.34±8.42ng/g lipid weight (lw) at delivery and 3.14±7.46ng/g lw at 6months of pregnancy, respectively. In cord blood serum, an average of 9.37±12.60ng/g lw was detected. Among the measured PBDE congeners, BDE-47, BDE-99 and BDE-153 were most dominant in both maternal and cord blood sera. Relatively higher levels of BDE-99 were detected in cord blood serum. Strong positive correlations were detected between maternal and cord blood serum samples, indicating the importance of maternal transfer. Health consequences of transplacental exposure to PBDEs among fetuses and newborn infants warrant further investigation. •Out of 19 PBDEs, 14 were detected in maternal and umbilical cord sera of Korea.•BDE-47 was predominant followed by BDE-99, or 153 in maternal and umbilical blood.•Trans-placental transfer ratio was 0.58 for BDE-47.•Exposure source could not be determined among dietary data, suggesting other major sources.