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Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids

Determination of cholic acid is very important and necessary in body fluids due to its both pharmaceutical and clinical significance. In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid...

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Published in:Materials Science & Engineering C 2014-09, Vol.42, p.436-442
Main Authors: Gültekin, Aytaç, Karanfil, Gamze, Sönmezoğlu, Savaş, Say, Rıdvan
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cited_by cdi_FETCH-LOGICAL-c433t-51226009ce6dbb14f93ae7c025666ac0f4f35e3e96cb9442b0f9bb98c3185e133
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description Determination of cholic acid is very important and necessary in body fluids due to its both pharmaceutical and clinical significance. In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid selective memories have been generated on QCM electrode surface by using molecularly imprinted polymer (MIP) based on methacryloylamidohistidine-copper (II) (MAH-Cu(II)) pre-organized monomer. The cholic acid imprinted nanosensor was characterized by atomic force microscopy (AFM) and then analytical performance of the cholic acid imprinted QCM nanosensor was studied. The detection limit was found to be 0.0065μM with linear range of 0.01–1000μM. Moreover, the high value of Langmuir constant (b) (7.3*105) obtained by Langmuir graph showed that the cholic acid imprinted nanosensor had quite strong binding sites affinity. At the last step of this procedure, cholic acid levels in body fluids were determined by the prepared imprinted QCM nanosensor. QCM responses of the cholic acid imprinted and non-imprinted nanosensors (CCA=0.1μM). [Display omitted] •The purpose is to synthesize a new cholic acid imprinted QCM nanosensor by MIP.•Analytical applications of QCM nanosensor were investigated.•The cholic acid levels in body fluids were determined by prepared QCM nanosensor.
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subjects Atomic force microscopy
Biocompatibility
Biomedical materials
Cholic acid
Cholic Acid - blood
Cholic Acid - chemistry
Cholic Acid - urine
Constants
Electrodes
Humans
Limit of Detection
Microbalances
Microscopy, Atomic Force
MIP
Molecular Imprinting - instrumentation
Molecular Imprinting - methods
Nanosensor
Nanostructure
Nanotechnology - instrumentation
Nanotechnology - methods
QCM
Quartz Crystal Microbalance Techniques - instrumentation
Quartz Crystal Microbalance Techniques - methods
Surface Properties
Surgical implants
title Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids
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