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Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids
Determination of cholic acid is very important and necessary in body fluids due to its both pharmaceutical and clinical significance. In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid...
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Published in: | Materials Science & Engineering C 2014-09, Vol.42, p.436-442 |
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description | Determination of cholic acid is very important and necessary in body fluids due to its both pharmaceutical and clinical significance. In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid selective memories have been generated on QCM electrode surface by using molecularly imprinted polymer (MIP) based on methacryloylamidohistidine-copper (II) (MAH-Cu(II)) pre-organized monomer. The cholic acid imprinted nanosensor was characterized by atomic force microscopy (AFM) and then analytical performance of the cholic acid imprinted QCM nanosensor was studied. The detection limit was found to be 0.0065μM with linear range of 0.01–1000μM. Moreover, the high value of Langmuir constant (b) (7.3*105) obtained by Langmuir graph showed that the cholic acid imprinted nanosensor had quite strong binding sites affinity. At the last step of this procedure, cholic acid levels in body fluids were determined by the prepared imprinted QCM nanosensor.
QCM responses of the cholic acid imprinted and non-imprinted nanosensors (CCA=0.1μM). [Display omitted]
•The purpose is to synthesize a new cholic acid imprinted QCM nanosensor by MIP.•Analytical applications of QCM nanosensor were investigated.•The cholic acid levels in body fluids were determined by prepared QCM nanosensor. |
doi_str_mv | 10.1016/j.msec.2014.05.055 |
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QCM responses of the cholic acid imprinted and non-imprinted nanosensors (CCA=0.1μM). [Display omitted]
•The purpose is to synthesize a new cholic acid imprinted QCM nanosensor by MIP.•Analytical applications of QCM nanosensor were investigated.•The cholic acid levels in body fluids were determined by prepared QCM nanosensor.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2014.05.055</identifier><identifier>PMID: 25063139</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Atomic force microscopy ; Biocompatibility ; Biomedical materials ; Cholic acid ; Cholic Acid - blood ; Cholic Acid - chemistry ; Cholic Acid - urine ; Constants ; Electrodes ; Humans ; Limit of Detection ; Microbalances ; Microscopy, Atomic Force ; MIP ; Molecular Imprinting - instrumentation ; Molecular Imprinting - methods ; Nanosensor ; Nanostructure ; Nanotechnology - instrumentation ; Nanotechnology - methods ; QCM ; Quartz Crystal Microbalance Techniques - instrumentation ; Quartz Crystal Microbalance Techniques - methods ; Surface Properties ; Surgical implants</subject><ispartof>Materials Science & Engineering C, 2014-09, Vol.42, p.436-442</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-51226009ce6dbb14f93ae7c025666ac0f4f35e3e96cb9442b0f9bb98c3185e133</citedby><cites>FETCH-LOGICAL-c433t-51226009ce6dbb14f93ae7c025666ac0f4f35e3e96cb9442b0f9bb98c3185e133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25063139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gültekin, Aytaç</creatorcontrib><creatorcontrib>Karanfil, Gamze</creatorcontrib><creatorcontrib>Sönmezoğlu, Savaş</creatorcontrib><creatorcontrib>Say, Rıdvan</creatorcontrib><title>Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Determination of cholic acid is very important and necessary in body fluids due to its both pharmaceutical and clinical significance. In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid selective memories have been generated on QCM electrode surface by using molecularly imprinted polymer (MIP) based on methacryloylamidohistidine-copper (II) (MAH-Cu(II)) pre-organized monomer. The cholic acid imprinted nanosensor was characterized by atomic force microscopy (AFM) and then analytical performance of the cholic acid imprinted QCM nanosensor was studied. The detection limit was found to be 0.0065μM with linear range of 0.01–1000μM. Moreover, the high value of Langmuir constant (b) (7.3*105) obtained by Langmuir graph showed that the cholic acid imprinted nanosensor had quite strong binding sites affinity. At the last step of this procedure, cholic acid levels in body fluids were determined by the prepared imprinted QCM nanosensor.
QCM responses of the cholic acid imprinted and non-imprinted nanosensors (CCA=0.1μM). [Display omitted]
•The purpose is to synthesize a new cholic acid imprinted QCM nanosensor by MIP.•Analytical applications of QCM nanosensor were investigated.•The cholic acid levels in body fluids were determined by prepared QCM nanosensor.</description><subject>Atomic force microscopy</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Cholic acid</subject><subject>Cholic Acid - blood</subject><subject>Cholic Acid - chemistry</subject><subject>Cholic Acid - urine</subject><subject>Constants</subject><subject>Electrodes</subject><subject>Humans</subject><subject>Limit of Detection</subject><subject>Microbalances</subject><subject>Microscopy, Atomic Force</subject><subject>MIP</subject><subject>Molecular Imprinting - instrumentation</subject><subject>Molecular Imprinting - methods</subject><subject>Nanosensor</subject><subject>Nanostructure</subject><subject>Nanotechnology - instrumentation</subject><subject>Nanotechnology - methods</subject><subject>QCM</subject><subject>Quartz Crystal Microbalance Techniques - instrumentation</subject><subject>Quartz Crystal Microbalance Techniques - methods</subject><subject>Surface Properties</subject><subject>Surgical implants</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkUurFDEQhYMo3vHqH3AhWbrpMe_pgBsZXxfuRQVdhzwqToZ0MnZ6BsZfb7dzdalQRS3qq1NwDkLPKVlTQtWr_Xpo4NeMULEmci75AK1ov-EdoZo-RCuiWd8JzekVetLanhDV8w17jK6YJIpTrlfo51s4Qa6HAcqEa8QW79L3XT7jBqWlKZ0A3918xs42CN2X7R0uttRlV0cc526Qwf_GAkwwDqnYKdWySPldzclj61PAefmCU8GuhjOO-ZhCe4oeRZsbPLuf1-jb-3dftx-7208fbrZvbjsvOJ86SRlThGgPKjhHRdTcwsYTJpVS1pMoIpfAQSvvtBDMkaid073ntJdAOb9GLy-6h7H-OEKbzJCah5xtgXpshirBmJac0v-jUmhGiNjIGWUX1I-1tRGiOYxpsOPZUGKWeMzeLPGYJR5D5FzL0Yt7_aMbIPw9-ZPHDLy-ADAbckowmuYTFA8hjbPPJtT0L_1feUChRA</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Gültekin, Aytaç</creator><creator>Karanfil, Gamze</creator><creator>Sönmezoğlu, Savaş</creator><creator>Say, Rıdvan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140901</creationdate><title>Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids</title><author>Gültekin, Aytaç ; 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In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid selective memories have been generated on QCM electrode surface by using molecularly imprinted polymer (MIP) based on methacryloylamidohistidine-copper (II) (MAH-Cu(II)) pre-organized monomer. The cholic acid imprinted nanosensor was characterized by atomic force microscopy (AFM) and then analytical performance of the cholic acid imprinted QCM nanosensor was studied. The detection limit was found to be 0.0065μM with linear range of 0.01–1000μM. Moreover, the high value of Langmuir constant (b) (7.3*105) obtained by Langmuir graph showed that the cholic acid imprinted nanosensor had quite strong binding sites affinity. At the last step of this procedure, cholic acid levels in body fluids were determined by the prepared imprinted QCM nanosensor.
QCM responses of the cholic acid imprinted and non-imprinted nanosensors (CCA=0.1μM). [Display omitted]
•The purpose is to synthesize a new cholic acid imprinted QCM nanosensor by MIP.•Analytical applications of QCM nanosensor were investigated.•The cholic acid levels in body fluids were determined by prepared QCM nanosensor.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25063139</pmid><doi>10.1016/j.msec.2014.05.055</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Atomic force microscopy Biocompatibility Biomedical materials Cholic acid Cholic Acid - blood Cholic Acid - chemistry Cholic Acid - urine Constants Electrodes Humans Limit of Detection Microbalances Microscopy, Atomic Force MIP Molecular Imprinting - instrumentation Molecular Imprinting - methods Nanosensor Nanostructure Nanotechnology - instrumentation Nanotechnology - methods QCM Quartz Crystal Microbalance Techniques - instrumentation Quartz Crystal Microbalance Techniques - methods Surface Properties Surgical implants |
title | Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids |
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