Highly efficient and eco-friendly one-pot synthesis of penta substitute pyrrole derivatives under catalyst-free conditions

An eco-friendly and efficient one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction of maldrum's acid, arylglyoxal monohydrate, dimethyl but-2-yne-dioate and amines under catalyst-free conditions in an environmentally friendly medium is described. The simple e...

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Bibliographic Details
Published in:International letters of chemistry, physics and astronomy physics and astronomy, 2014-01, Vol.11 (3), p.257-257
Main Authors: Viradiya, Denish J, Baria, Bharat H, Kakadiya, Rajesh, Kotadiya, Vipul C, Shah, Anamik
Format: Article
Language:English
Subjects:
Astronomy
Catalysts
Conversion
Derivatives
Dimethyl
Purification
Pyrroles
Synthesis
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Summary:An eco-friendly and efficient one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction of maldrum's acid, arylglyoxal monohydrate, dimethyl but-2-yne-dioate and amines under catalyst-free conditions in an environmentally friendly medium is described. The simple experimental procedure, catalyst-free reaction conditions, short period of conversion, and excellent yields are the advantages of the present method. Good chemical yields have been achieved without the need for chromatography and recrystallization or other purification methods.
ISSN:2299-3843