Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l...

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Bibliographic Details
Published in:Biotechnology letters 1998-02, Vol.20 (2), p.149-151
Main Authors: SON, K.-H, HONG, S.-H, KWON, Y.-K, BAE, K.-S, KIM, Y.-K, KWON, B.-M, KIM, S.-U, BOK, S.-H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Enzyme engineering
Fermentation
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Phosphates
Potassium
Production of selected enzymes
Protease inhibitors
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Summary:Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.[PUBLICATION ABSTRACT]
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1005324407319