Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats

• Published in: European journal of pharmacology 1997-05, Vol.327 (2), p.109-115
• Main Authors: Tang, Ellen, Yip, Ping K, Chapman, Astrid G, Jane, David E, Meldrum, Brian S
• Format: Article
• Language: English
• Subjects: ( S)-4C3HPG) (( S)-4-carboxy-3-hydroxyphenylglycine; (1 S,3 S)-ACPD ((1 S,3 S)-1-aminocyclopentane-1,3-dicarboxylic acid); Animals; Anticonvulsants. Antiepileptics. Antiparkinson agents; Behavior, Animal - drug effects; Biological and medical sciences; Cycloleucine - analogs & derivatives; Cycloleucine - pharmacology; Dose-Response Relationship, Drug; Epilepsy; Epilepsy - drug therapy; Epilepsy - etiology; Female; Genetically epilepsy-prone rat; Glutamate; Glycine - analogs & derivatives; Glycine - pharmacology; Inferior Colliculi - drug effects; l-Serine- O-phosphate; Male; Medical sciences; Metabotropic glutamate receptor; Neuropharmacology; Neuroprotective Agents - pharmacology; Noise; Pharmacology. Drug treatments; Phosphoserine - pharmacology; Rats; Receptors, Metabotropic Glutamate - agonists; Receptors, Metabotropic Glutamate - antagonists & inhibitors
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(97)89649-5

The anticonvulsant activity of ( S)-4-carboxy-3-hydroxyphenylglycine (( S)-4C3HPG) (an antagonist of Group I and an agonist of Group II metabotropic glutamate (mGlu) receptors), of (1 S,3 S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1 S,3 S)-ACPD) (an agonist of Group II mGlu receptors), and of l-serine- O-phosphate (an agonist of Group III mGlu receptors) was studied against sound-induced seizures in genetically epilepsy-prone (GEP) rats following bilateral microinjection into the inferior colliculus. All 3 drugs produce dose-dependent suppression of all phases of sound-induced seizures (wild running, clonic and tonic). ( S)-4C3HPG produces an immediate and short-lasting (