Effect of some plants' extracts used in Sudanese folkloric medicines on carrageenan-induced inflammation

• Published in: Pakistan journal of pharmaceutical sciences 2015-01, Vol.28 (1), p.159-165
• Main Authors: Mohammed, Mona Salih, Khalid, Hassan Subki, Muddathir, Abd Elkhaliq, El-Tahir, Kamal, Khan, Azmat Ali, Algadir, Haidar Abd, Osman, Wadah Jamal Ahmed, Siddiqui, Nasir Ali
• Format: Article
• Language: English
• Subjects: Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Care and treatment; Carrageenan; Disease Models, Animal; Folklore; Health aspects; Humans; Inflammation; Inflammation - chemically induced; Inflammation - prevention & control; Injections, Intraperitoneal; Male; Medicinal plants; Medicine, Traditional; Methanol - chemistry; Methylene Chloride - chemistry; Phytotherapy; Plant extracts; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plants, Medicinal; Rats, Wistar; Solvents - chemistry; Sudan
• ISSN: 1011-601X

Investigations for anti-inflammatory potential and categorization of Sudanese medicinal plants according to their potency. Anti-inflammatory effect of plants' extracts of 17 genera were studied using the carrageenan induced inflammation in rats' paws. The plant extracts were obtained using methanol and dichloromethane as solvent and administered intra peritoneally at the concentration of 2g/kg body weight. The results obtained in this experiment strongly support and validate the traditional uses of these Sudanese medicinal plants to treat various inflammatory diseases. 63.9% of plants extracts showed marked inhibition of inflammation induced by carrageenan (78.3% out of this percentage represented by methanolic extract), 27.8% showed no activity and 8.3% enhanced the carrageenan induced inflammation. The anti-inflammatory effect of many of these plants has not been reported previously, yet they have been extensively used in Sudanese folkloric medicine. The result of this study justify the traditional medicinal use of the evaluated plants species in treating inflammatory disorders and helped in categorizing the investigated plants into most useful, moderately useful and least useful category for inflammatory diseases. Out of the 17 investigated plant species 05 belongs to most useful and 06 belongs to moderately useful category. However, toxicity studies are required to prove the safety of these plant materials.