Correction of metabolic acidosis in hemodialysis: consequences on serum leptin and mineral metabolism

• Published in: International urology and nephrology 2015-01, Vol.47 (1), p.177-182
• Main Authors: Bales, Alessandra M., Moysés, Rosa M. A., dos Reis, Luciene M., Graciolli, Fabiana G., Hung, James, Martins Castro, Manuel Carlos, Elias, Rosilene M.
• Format: Article
• Language: English
• Subjects: Acidosis - blood; Acidosis - therapy; Adiponectin - blood; Adult; beta 2-Microglobulin - blood; Bicarbonates - administration & dosage; Bicarbonates - blood; Blood Gas Analysis; Calcium - blood; Dialysis Solutions - chemistry; Female; Humans; Hydrogen-Ion Concentration; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Leptin - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Nephrology - Original Paper; Parathyroid Hormone - blood; Phosphates - blood; Prospective Studies; Renal Dialysis; Serum Albumin - metabolism; Sex Factors; Urology; Young Adult
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-014-0844-5

Purpose Hyperleptinemia and metabolic acidosis (MA) are frequently observed in patients on hemodialysis (HD). While the role of leptin in patients on HD is not completely understood, HD only partially corrects MA. Both leptin and acidosis have effect on bone disease. The goal of the present study was to evaluate the effects of MA correction on chronic kidney disease–mineral and bone disorder laboratory parameters and leptin levels. Methods Forty-eight patients on HD, aged 43 ± 19 years, were prospectively studied. Individual adjustments in the bicarbonate dialysate concentration were made to maintain pre-dialysis concentration ≥22 mEq/l. Blood gas analysis was done monthly for 4 months (M1–M4). Results From M0 to M4, serum albumin increased (from 3.5 ± 0.3 to 4.0 ± 0.3 g/l, p