High prevalence of carbapenem resistance among plasmid-mediated AmpC β-lactamase-producing Klebsiella pneumoniae during outbreaks in liver transplantation units

Highlights • Outbreaks due to DHA-1-or CMY-2-producing K. pneumoniae strains occurred. • Carbamenem resistant variants with porin loss were frequently found. • Outbreak strains caused bloodstream infections with high mortality.

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Bibliographic Details
Published in:International journal of antimicrobial agents 2015-01, Vol.45 (1), p.33-40
Main Authors: Matsumura, Yasufumi, Tanaka, Michio, Yamamoto, Masaki, Nagao, Miki, Machida, Kiyomasa, Ito, Yutaka, Takakura, Shunji, Ogawa, Kohei, Yoshizawa, Atsushi, Fujimoto, Yasuhiro, Okamoto, Shinya, Uemoto, Shinji, Ichiyama, Satoshi
Format: Article
Language:English
Subjects:
Adult
Aged
AmpC
Anti-Bacterial Agents - pharmacology
Bacteremia - epidemiology
Bacteremia - microbiology
Bacterial Proteins - genetics
beta-Lactam Resistance
beta-Lactamases - genetics
Carbapenems
Carbapenems - pharmacology
Case-Control Studies
Disease Outbreaks
DNA, Bacterial - genetics
Female
Hospitals, University
Humans
Infection Control
Infectious Disease
Japan
Klebsiella Infections - epidemiology
Klebsiella Infections - microbiology
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - isolation & purification
Liver Transplantation
Male
Middle Aged
Molecular epidemiology
Multilocus Sequence Typing
Outer membrane protein
Plasmids
Polymerase Chain Reaction
Young Adult
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Description
Summary:Highlights • Outbreaks due to DHA-1-or CMY-2-producing K. pneumoniae strains occurred. • Carbamenem resistant variants with porin loss were frequently found. • Outbreak strains caused bloodstream infections with high mortality.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2014.08.015