A comparative analysis of sinonasal and salivary gland mucoepidermoid carcinoma using population-based data

Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. Primary sinonasal MEC (SN‐MEC) is rare. This study analyzes the demographic, clinicopathologic, and survival characteristics of SN‐MEC and establishes comparisons with primary major SG‐MEC. Methods The Surve...

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Bibliographic Details
Published in:International forum of allergy & rhinology 2015-01, Vol.5 (1), p.78-84
Main Authors: Patel, Tapan D., Vázquez, Alejandro, Patel, Dhruv M., Baredes, Soly, Eloy, Jean Anderson
Format: Article
Language:English
Subjects:
Age Factors
Aged
Carcinoma, Mucoepidermoid - diagnosis
Carcinoma, Mucoepidermoid - mortality
Carcinoma, Mucoepidermoid - pathology
Databases, Factual
Female
Humans
Male
Middle Aged
mucoepidermoid carcinoma
nasal cancer
Neoplasm Staging
Nose Neoplasms - diagnosis
Nose Neoplasms - mortality
Nose Neoplasms - pathology
paranasal sinus neoplasm
Paranasal Sinuses - pathology
Population Groups
Prognosis
salivary gland carcinoma
Salivary Gland Neoplasms - diagnosis
Salivary Gland Neoplasms - mortality
Salivary Gland Neoplasms - pathology
SEER
sinonasal cancer
Survival Analysis
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Summary:Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. Primary sinonasal MEC (SN‐MEC) is rare. This study analyzes the demographic, clinicopathologic, and survival characteristics of SN‐MEC and establishes comparisons with primary major SG‐MEC. Methods The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2010) was queried for SN‐MEC (149 cases) and SG‐MEC (4234 cases). Data were analyzed comparatively with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan‐Meier and Cox proportional hazards models. Results Mean ±  standard deviation (SD) age at diagnosis for SN‐MEC was 58.6 ±  16.6 years. High histologic grade (ie, grades III and IV) at the time of diagnosis was more common among SN‐MEC than SG‐MEC (42.3% vs 25.5%, p 
ISSN:2042-6976
2042-6984
DOI:10.1002/alr.21422