Cowden syndrome: Recognizing and managing a not-so-rare hereditary cancer syndrome

Cowden syndrome (CS) is an autosomal dominant hereditary cancer syndrome causing increased risk for breast, thyroid, renal, uterine, and other cancers as well as benign neoplasias and neurodevelopmental concerns. Timely diagnosis of affected patients is key, as early recognition allows for high‐risk...

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Bibliographic Details
Published in:Journal of surgical oncology 2015-01, Vol.111 (1), p.125-130
Main Authors: Mester, Jessica, Eng, Charis
Format: Article
Language:English
Subjects:
3-5
cowden syndrome
Hamartoma Syndrome, Multiple - diagnosis
Hamartoma Syndrome, Multiple - genetics
Hamartoma Syndrome, Multiple - therapy
hereditary cancer syndromes
Humans
Mutation - genetics
Neoplastic Syndromes, Hereditary - diagnosis
Neoplastic Syndromes, Hereditary - genetics
Neoplastic Syndromes, Hereditary - therapy
PTEN hamartoma tumor syndrome
PTEN Phosphohydrolase - genetics
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Summary:Cowden syndrome (CS) is an autosomal dominant hereditary cancer syndrome causing increased risk for breast, thyroid, renal, uterine, and other cancers as well as benign neoplasias and neurodevelopmental concerns. Timely diagnosis of affected patients is key, as early recognition allows for high‐risk screening and other preventative measures prior to a patient enduring multiple cancer diagnoses. This review will highlight the cardinal features of CS and management recommendations for affected patients. J. Surg. Oncol. 2015 111:125–130. © 2014 Wiley Periodicals, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.23735