Evaluation of serogroup C and ACWY meningococcal vaccine programs: Projected impact on disease burden according to a stochastic two-strain dynamic model

Highlights • Multi-strain dynamic models can be useful for meningococcal vaccine decision-making. • Monovalent C vaccine is predicted to cause strain replacement in the long-term. • Infant plus adolescent ACWY vaccination is predicted to be the most effective.

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Bibliographic Details
Published in:Vaccine 2015-01, Vol.33 (1), p.268-275
Main Authors: Vickers, David M, Anonychuk, Andrea M, De Wals, Philippe, Demarteau, Nadia, Bauch, Chris T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Advisory committees
Age
Aged
Aged, 80 and over
Allergy and Immunology
Bacteremia - epidemiology
Bacteremia - microbiology
Bacteremia - prevention & control
Canada - epidemiology
Child, Preschool
Dynamic model
Epidemiology
Female
Humans
Immunization
Immunization Programs
Infant
Infant, Newborn
Infants
Infections
Invasive meningococcal disease
Male
Meningitis
Meningitis, Bacterial - epidemiology
Meningitis, Bacterial - microbiology
Meningitis, Bacterial - prevention & control
Meningococcal Infections - epidemiology
Meningococcal Infections - microbiology
Meningococcal Infections - prevention & control
Meningococcal vaccines
Meningococcal Vaccines - administration & dosage
Meningococcal Vaccines - immunology
Middle Aged
Models, Statistical
Mortality
Neisseria meningitidis
Neisseria meningitidis - classification
Neisseria meningitidis - isolation & purification
Population
Sensitivity analysis
Serogroup
Stochastic model
Strain replacement
Teenagers
Vaccines
Young Adult
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Description
Summary:Highlights • Multi-strain dynamic models can be useful for meningococcal vaccine decision-making. • Monovalent C vaccine is predicted to cause strain replacement in the long-term. • Infant plus adolescent ACWY vaccination is predicted to be the most effective.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.09.034