Crucial First Steps: The Transcriptional Control of Neuron Delamination

A crucial event in the birth of a neuron is the detachment of its apical process from the neuroepithelium. In this issue of Neuron, Rousso et al. (2012) show that repression of N-cadherin by Foxp transcription factors disrupts apical adherens junctions and triggers neurogenesis.

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2012-04, Vol.74 (2), p.209-211
Main Authors: Pacary, Emilie, Martynoga, Ben, Guillemot, François
Format: Article
Language:English
Subjects:
Cell adhesion & migration
Genes
Genetic engineering
Neurogenesis
Neurons
Proteins
Rodents
Spinal cord
Transcription factors
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Description
Summary:A crucial event in the birth of a neuron is the detachment of its apical process from the neuroepithelium. In this issue of Neuron, Rousso et al. (2012) show that repression of N-cadherin by Foxp transcription factors disrupts apical adherens junctions and triggers neurogenesis.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2012.04.002