Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study

Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretro...

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Bibliographic Details
Published in:The Journal of infectious diseases 2013-11, Vol.208 (9), p.1454-1458
Main Authors: Wandeler, Gilles, Gsponer, Thomas, Bihl, Florian, Bernasconi, Enos, Cavassini, Matthias, Kovari, Helen, Schmid, Patrick, Battegay, Manuel, Calmy, Alexandra, Egger, Matthias, Furrer, Hansjakob, Rauch, Andri
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Biological and medical sciences
CD4 Lymphocyte Count
Coinfection - drug therapy
Coinfection - immunology
Coinfection - virology
Female
Fundamental and applied biological sciences. Psychology
Hepatitis B virus
Hepatitis B virus - drug effects
Hepatitis B virus - immunology
Hepatitis B, Chronic - drug therapy
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - virology
HIV - drug effects
HIV - immunology
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Prospective Studies
Treatment Outcome
Viral diseases
Viral hepatitis
Virology
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Summary:Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jit351