Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia

• Published in: Cancer letters 2014-11, Vol.354 (2), p.272-280
• Main Authors: Zhang, Li Feng, Tan, Darren Qian Cheng, Jeyasekharan, Anand D, Hsieh, Wen Son, Ho, Anh Son, Ichiyama, Koji, Ye, Min, Pang, Brendan, Ohba, Kenji, Liu, Xin, de Mel, Sanjay, Cuong, Bui Khac, Chng, Wee Joo, Ryo, Akihide, Suzuki, Youichi, Yeoh, Khay Guan, Toan, Nguyen Linh, Yamamoto, Naoki
• Format: Article
• Language: English
• Subjects: Acute myeloid leukemia; Adult; Animals; Apoptosis; Cancer; Cercopithecus aethiops; Cytopathogenic Effect, Viral; Hematology; Hematology, Oncology and Palliative Medicine; Humans; Immunotherapy; Infections; Jurkat Cells; Laboratories; Leukemia, Myeloid, Acute - therapy; Leukemia, Myeloid, Acute - virology; Male; Measles; Measles virus; Measles virus - immunology; Measles virus - physiology; Mice; Mice, Inbred BALB C; Mice, Nude; Mumps; Mumps virus; Mumps virus - immunology; Mumps virus - physiology; Oncolytic Virotherapy - methods; Oncolytic virus; Tumors; U937 Cells; Vaccines; Vero Cells; Viruses; Xenograft Model Antitumor Assays
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2014.08.034

Highlights • Combination of vaccine-derived measles and mumps viruses (MM) synergistically killed many hematopoietic cancer cell lines including acute myeloid leukemia (AML) cells due to increased apoptosis induction. • MM displayed greater tumor suppression and prolonged survival in an U937 xenograft AML mouse model. • Furthermore, MM efficiently killed blasts from AML patients and elicited more efficient killing effect when co-administered with Ara-C. • Hence MM is a promising therapeutic candidate for hematological malignancies.